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Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer
BACKGROUND: This study aimed to compare the NR3C1 expression among cancer patients with major depressive disorder (cancer depression), cancer patients without major depressive disorder (cancer non-depression), and major depressive disorder patients without cancer (general depression), as a prelimina...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AVES
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797698/ https://www.ncbi.nlm.nih.gov/pubmed/36628383 http://dx.doi.org/10.5152/alphapsychiatry.2022.22944 |
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author | Shim, In Hee Yi, Joo Mi Ha, Su Hong Kwon, Kyung A Bae, Dong Sik |
author_facet | Shim, In Hee Yi, Joo Mi Ha, Su Hong Kwon, Kyung A Bae, Dong Sik |
author_sort | Shim, In Hee |
collection | PubMed |
description | BACKGROUND: This study aimed to compare the NR3C1 expression among cancer patients with major depressive disorder (cancer depression), cancer patients without major depressive disorder (cancer non-depression), and major depressive disorder patients without cancer (general depression), as a preliminary investigation of epigenetic changes in the glucocorticoid receptor gene. METHODS: From May 2019 to November 2019, patients were recruited from the Department of Psychiatry, Cancer Center in Busan, Korea. For gene expression studies, primers were designed using the Primer3 web tool (http://frodo.wi.mit.edu/primer3), and amplification reactions were performed. RESULTS: Expression levels of NR3C1 were lower in cancer depression and general depression than in cancer non-depression group. Given that we observed downregulation of the NR3C1 gene expression in depressive patients regardless of cancer status, it appears that methylation changes in NR3C1 may contribute to the pathophysiology of depression. CONCLUSION: The results of this study imply that the expression of NR3C1 may be decreased in major depressive disorder. |
format | Online Article Text |
id | pubmed-9797698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AVES |
record_format | MEDLINE/PubMed |
spelling | pubmed-97976982023-01-09 Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer Shim, In Hee Yi, Joo Mi Ha, Su Hong Kwon, Kyung A Bae, Dong Sik Alpha Psychiatry Original Article BACKGROUND: This study aimed to compare the NR3C1 expression among cancer patients with major depressive disorder (cancer depression), cancer patients without major depressive disorder (cancer non-depression), and major depressive disorder patients without cancer (general depression), as a preliminary investigation of epigenetic changes in the glucocorticoid receptor gene. METHODS: From May 2019 to November 2019, patients were recruited from the Department of Psychiatry, Cancer Center in Busan, Korea. For gene expression studies, primers were designed using the Primer3 web tool (http://frodo.wi.mit.edu/primer3), and amplification reactions were performed. RESULTS: Expression levels of NR3C1 were lower in cancer depression and general depression than in cancer non-depression group. Given that we observed downregulation of the NR3C1 gene expression in depressive patients regardless of cancer status, it appears that methylation changes in NR3C1 may contribute to the pathophysiology of depression. CONCLUSION: The results of this study imply that the expression of NR3C1 may be decreased in major depressive disorder. AVES 2022-11-01 /pmc/articles/PMC9797698/ /pubmed/36628383 http://dx.doi.org/10.5152/alphapsychiatry.2022.22944 Text en © Copyright 2022 authors https://creativecommons.org/licenses/by-nc/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Article Shim, In Hee Yi, Joo Mi Ha, Su Hong Kwon, Kyung A Bae, Dong Sik Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title | Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title_full | Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title_fullStr | Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title_full_unstemmed | Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title_short | Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer |
title_sort | glucocorticoid receptor gene (nr3c1) expression in the pathogenesis of depression in cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797698/ https://www.ncbi.nlm.nih.gov/pubmed/36628383 http://dx.doi.org/10.5152/alphapsychiatry.2022.22944 |
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