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Can G-quadruplex become a promising target in HBV therapy?

The chronic infection with hepatitis B virus (HBV) is an important health problem that affects millions of people worldwide. Current therapies for HBV always suffer from a poor response rate, common side effects, and the need for lifelong treatment. Novel therapeutic targets are expected. Interestin...

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Detalles Bibliográficos
Autores principales: Teng, Ye, Zhu, Ming, Chi, Yuan, Li, Lijing, Jin, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797731/
https://www.ncbi.nlm.nih.gov/pubmed/36591216
http://dx.doi.org/10.3389/fimmu.2022.1091873
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author Teng, Ye
Zhu, Ming
Chi, Yuan
Li, Lijing
Jin, Ye
author_facet Teng, Ye
Zhu, Ming
Chi, Yuan
Li, Lijing
Jin, Ye
author_sort Teng, Ye
collection PubMed
description The chronic infection with hepatitis B virus (HBV) is an important health problem that affects millions of people worldwide. Current therapies for HBV always suffer from a poor response rate, common side effects, and the need for lifelong treatment. Novel therapeutic targets are expected. Interestingly, non-canonical structures of nucleic acids play crucial roles in the regulation of gene expression. Especially the formation of G-quadruplexes (G4s) in G-rich strands has been demonstrated to affect many bioprocesses including replication, transcription, and translation, showing great potential as targets in anticancer and antiviral therapies. In this review, we summarize recent antiviral studies about G4s and discuss the potential roles of G4 structures in antiviral therapy for HBV.
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spelling pubmed-97977312022-12-30 Can G-quadruplex become a promising target in HBV therapy? Teng, Ye Zhu, Ming Chi, Yuan Li, Lijing Jin, Ye Front Immunol Immunology The chronic infection with hepatitis B virus (HBV) is an important health problem that affects millions of people worldwide. Current therapies for HBV always suffer from a poor response rate, common side effects, and the need for lifelong treatment. Novel therapeutic targets are expected. Interestingly, non-canonical structures of nucleic acids play crucial roles in the regulation of gene expression. Especially the formation of G-quadruplexes (G4s) in G-rich strands has been demonstrated to affect many bioprocesses including replication, transcription, and translation, showing great potential as targets in anticancer and antiviral therapies. In this review, we summarize recent antiviral studies about G4s and discuss the potential roles of G4 structures in antiviral therapy for HBV. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9797731/ /pubmed/36591216 http://dx.doi.org/10.3389/fimmu.2022.1091873 Text en Copyright © 2022 Teng, Zhu, Chi, Li and Jin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Teng, Ye
Zhu, Ming
Chi, Yuan
Li, Lijing
Jin, Ye
Can G-quadruplex become a promising target in HBV therapy?
title Can G-quadruplex become a promising target in HBV therapy?
title_full Can G-quadruplex become a promising target in HBV therapy?
title_fullStr Can G-quadruplex become a promising target in HBV therapy?
title_full_unstemmed Can G-quadruplex become a promising target in HBV therapy?
title_short Can G-quadruplex become a promising target in HBV therapy?
title_sort can g-quadruplex become a promising target in hbv therapy?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797731/
https://www.ncbi.nlm.nih.gov/pubmed/36591216
http://dx.doi.org/10.3389/fimmu.2022.1091873
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