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The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease

BACKGROUND: Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease...

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Autores principales: Öztekin, Yeşim, Güneş, Fatma Esra, Özen Alahdab, Yeşim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797792/
https://www.ncbi.nlm.nih.gov/pubmed/36510401
http://dx.doi.org/10.5152/tjg.2022.21815
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author Öztekin, Yeşim
Güneş, Fatma Esra
Özen Alahdab, Yeşim
author_facet Öztekin, Yeşim
Güneş, Fatma Esra
Özen Alahdab, Yeşim
author_sort Öztekin, Yeşim
collection PubMed
description BACKGROUND: Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability. METHODS: The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients’ compliance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores. RESULTS: Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were compliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05). CONCLUSION: The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet.
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spelling pubmed-97977922023-01-04 The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease Öztekin, Yeşim Güneş, Fatma Esra Özen Alahdab, Yeşim Turk J Gastroenterol Original Article BACKGROUND: Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability. METHODS: The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients’ compliance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores. RESULTS: Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were compliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05). CONCLUSION: The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet. Turkish Society of Gastroenterology 2022-12-01 /pmc/articles/PMC9797792/ /pubmed/36510401 http://dx.doi.org/10.5152/tjg.2022.21815 Text en © Copyright 2022 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Öztekin, Yeşim
Güneş, Fatma Esra
Özen Alahdab, Yeşim
The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title_full The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title_fullStr The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title_full_unstemmed The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title_short The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
title_sort investigation of nutritional status, intestinal permeability, and quality of life in people with celiac disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797792/
https://www.ncbi.nlm.nih.gov/pubmed/36510401
http://dx.doi.org/10.5152/tjg.2022.21815
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