Cargando…

Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer

BACKGROUND: Extracellular vesicles secreted by tumor cells contain double-stranded DNA called extracellular vesicle DNA (evDNA). EvDNA is genomic DNA that reflects cancer driver mutations. However, the significance of evDNA analysis in the diagnosis and surveillance of colon cancer remains unclear....

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Jeesoo, Cho, Ho Yeon, Jeon, Jeongseok, Kim, Kyung-A, Han, Yoon Dae, Ahn, Joong Bae, Wortzel, Inbal, Lyden, David, Kim, Han Sang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797818/ https://www.ncbi.nlm.nih.gov/pubmed/36591510 http://dx.doi.org/10.3389/fonc.2022.1067210

Ejemplares similares

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
por: Chen, Walter W, et al.
Publicado: (2013)

KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
por: Luo, Yuming, et al.
Publicado: (2022)

Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach
por: Pender, Alexandra, et al.
Publicado: (2015)

Extracellular vesicles are the primary source of blood‐borne tumour‐derived mutant KRAS DNA early in pancreatic cancer
por: Hagey, Daniel W., et al.
Publicado: (2021)

Detection of KRAS G12D in colorectal cancer stool by droplet digital PCR
por: Olmedillas-López, Susana, et al.
Publicado: (2017)

Serum-Based KRAS(G12/G13) Mutation Detection Using Droplet Digital PCR: Clinical Implications and Limitations in Colorectal Adenocarcinoma With Tumor Heterogeneity
por: Kim, Ju Seok, et al.
Publicado: (2021)

Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation Sequencing
por: Demuth, Christina, et al.
Publicado: (2018)

Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth
por: Kim, Wonjoo, et al.
Publicado: (2018)

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix
por: Kim, Jin K., et al.
Publicado: (2021)

Clinical features and KRAS mutation in colorectal cancer with bone metastasis
por: Park, Hyung Soon, et al.
Publicado: (2020)

Micro-injection Molded Droplet Generation System for Digital PCR Application
por: Jo, Daae, et al.
Publicado: (2022)

Quantitative evaluation of the molecular marker using droplet digital PCR
por: Shin, Wonseok, et al.
Publicado: (2020)

KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer
por: Pirlog, Radu, et al.
Publicado: (2022)

Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis
por: Banijamali, Mahsan, et al.
Publicado: (2022)

Evaluation of droplet digital PCR and next generation sequencing for characterizing DNA reference material for KRAS mutation detection
por: Dong, Lianhua, et al.
Publicado: (2018)

Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers
por: Adachi, Yuta, et al.
Publicado: (2021)

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2019)

The Role of Extracellular Vesicles in Senescence
por: Oh, Chaehwan, et al.
Publicado: (2022)

Analysis of KRAS Mutation Subtype in Tissue DNA and Cell-Free DNA Using Droplet Digital PCR and the Function of Cell-Free DNA as a Recurrence Predictive Marker in Pancreatic Cancer
por: Jun, Eunsung, et al.
Publicado: (2021)

Alternative Splicing of MAPKs in the Regulation of Signaling Specificity
por: Maik-Rachline, Galia, et al.
Publicado: (2021)

Comparison of droplet digital PCR and quantitative real-time PCR in mcrA-based methanogen community analysis
por: Kim, Tae Gwan, et al.
Publicado: (2014)

A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS
por: Pang, Xiufeng, et al.
Publicado: (2016)

An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth
por: Sriwastva, Mukesh K., et al.
Publicado: (2023)

Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2020)

KRAS G12V Mutation Detection by Droplet Digital PCR in Circulating Cell-Free DNA of Colorectal Cancer Patients
por: Olmedillas López, Susana, et al.
Publicado: (2016)

Defeat mutant KRAS with synthetic lethality
por: Pang, Xiufeng, et al.
Publicado: (2016)

Primary endocrine resistance of ER+ breast cancer with ESR1 mutations interrogated by droplet digital PCR
por: Ahn, Sung Gwe, et al.
Publicado: (2022)

Mutational status of TP53 defines the efficacy of Wee1 inhibitor AZD1775 in KRAS-mutant non-small cell lung cancer
por: Ku, Bo Mi, et al.
Publicado: (2017)

Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges
por: Lee, Ji Yong, et al.
Publicado: (2021)

Comparative analysis of HER2 copy number between plasma and tissue samples in gastric cancer using droplet digital PCR
por: Kim, Boram, et al.
Publicado: (2020)

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
por: Bery, Nicolas, et al.
Publicado: (2020)

Improvement of digital PCR conditions for direct detection of KRAS mutations
por: Lee, Jina, et al.
Publicado: (2020)

Applying imaging flow cytometry and immunofluorescence in studying the dynamic Golgi structure in cultured cells
por: Wortzel, Inbal, et al.
Publicado: (2022)

Making Droplet-Embedded Vesicles to Model Cellular Lipid Droplets
por: Chorlay, Aymeric, et al.
Publicado: (2020)

microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells
por: Jeon, Jin Seok, et al.
Publicado: (2020)

Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory
por: Ryu, Hyun-Hee, et al.
Publicado: (2020)

KRAS mutant colorectal tumors: Past and present
por: Brand, Toni M., et al.
Publicado: (2012)

Distinct metabolic preference of atypical KRAS mutant
por: Cheong, Heesun
Publicado: (2020)

Current therapy of KRAS-mutant lung cancer
por: Ghimessy, Aron, et al.
Publicado: (2020)

Small molecular inhibitors for KRAS-mutant cancers
por: Wu, Xuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_00kuokhtmeu8i29ir6v66n7hp9