Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radi...

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Detalles Bibliográficos
Autores principales: Kao, Chien-Hsiang, Liu, Chien-Ting, Lin, Hao, Huang, Yung-Cheng, Lan, Jui, Ou, Yu-Che, Fu, Hung-Chun, Wu, Chen-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797856/
https://www.ncbi.nlm.nih.gov/pubmed/36591227
http://dx.doi.org/10.3389/fimmu.2022.1079253
Descripción
Sumario:Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.

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