Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radi...

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Autores principales: Kao, Chien-Hsiang, Liu, Chien-Ting, Lin, Hao, Huang, Yung-Cheng, Lan, Jui, Ou, Yu-Che, Fu, Hung-Chun, Wu, Chen-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797856/
https://www.ncbi.nlm.nih.gov/pubmed/36591227
http://dx.doi.org/10.3389/fimmu.2022.1079253
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author Kao, Chien-Hsiang
Liu, Chien-Ting
Lin, Hao
Huang, Yung-Cheng
Lan, Jui
Ou, Yu-Che
Fu, Hung-Chun
Wu, Chen-Hsuan
author_facet Kao, Chien-Hsiang
Liu, Chien-Ting
Lin, Hao
Huang, Yung-Cheng
Lan, Jui
Ou, Yu-Che
Fu, Hung-Chun
Wu, Chen-Hsuan
author_sort Kao, Chien-Hsiang
collection PubMed
description Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.
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spelling pubmed-97978562022-12-30 Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma Kao, Chien-Hsiang Liu, Chien-Ting Lin, Hao Huang, Yung-Cheng Lan, Jui Ou, Yu-Che Fu, Hung-Chun Wu, Chen-Hsuan Front Immunol Immunology Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9797856/ /pubmed/36591227 http://dx.doi.org/10.3389/fimmu.2022.1079253 Text en Copyright © 2022 Kao, Liu, Lin, Huang, Lan, Ou, Fu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kao, Chien-Hsiang
Liu, Chien-Ting
Lin, Hao
Huang, Yung-Cheng
Lan, Jui
Ou, Yu-Che
Fu, Hung-Chun
Wu, Chen-Hsuan
Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title_full Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title_fullStr Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title_full_unstemmed Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title_short Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
title_sort case report: durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797856/
https://www.ncbi.nlm.nih.gov/pubmed/36591227
http://dx.doi.org/10.3389/fimmu.2022.1079253
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