Advances in co-opting anti-depressant drugs in glioma therapy

A study by Chryplewicz et al. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compa...

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Detalles Bibliográficos
Autores principales: Pant, Ayush, Lim, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797942/
https://www.ncbi.nlm.nih.gov/pubmed/36543105
http://dx.doi.org/10.1016/j.xcrm.2022.100837
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author Pant, Ayush
Lim, Michael
author_facet Pant, Ayush
Lim, Michael
author_sort Pant, Ayush
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description A study by Chryplewicz et al. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compartments in glioma.
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spelling pubmed-97979422022-12-30 Advances in co-opting anti-depressant drugs in glioma therapy Pant, Ayush Lim, Michael Cell Rep Med Spotlight A study by Chryplewicz et al. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compartments in glioma. Elsevier 2022-12-20 /pmc/articles/PMC9797942/ /pubmed/36543105 http://dx.doi.org/10.1016/j.xcrm.2022.100837 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Pant, Ayush
Lim, Michael
Advances in co-opting anti-depressant drugs in glioma therapy
title Advances in co-opting anti-depressant drugs in glioma therapy
title_full Advances in co-opting anti-depressant drugs in glioma therapy
title_fullStr Advances in co-opting anti-depressant drugs in glioma therapy
title_full_unstemmed Advances in co-opting anti-depressant drugs in glioma therapy
title_short Advances in co-opting anti-depressant drugs in glioma therapy
title_sort advances in co-opting anti-depressant drugs in glioma therapy
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797942/
https://www.ncbi.nlm.nih.gov/pubmed/36543105
http://dx.doi.org/10.1016/j.xcrm.2022.100837
work_keys_str_mv AT pantayush advancesincooptingantidepressantdrugsingliomatherapy
AT limmichael advancesincooptingantidepressantdrugsingliomatherapy

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