Correlations between complex human phenotypes vary by genetic background, gender, and environment

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from...

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Detalles Bibliográficos
Autores principales: Elgart, Michael, Goodman, Matthew O., Isasi, Carmen, Chen, Han, Morrison, Alanna C., de Vries, Paul S., Xu, Huichun, Manichaikul, Ani W., Guo, Xiuqing, Franceschini, Nora, Psaty, Bruce M., Rich, Stephen S., Rotter, Jerome I., Lloyd-Jones, Donald M., Fornage, Myriam, Correa, Adolfo, Heard-Costa, Nancy L., Vasan, Ramachandran S., Hernandez, Ryan, Kaplan, Robert C., Redline, Susan, Sofer, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797952/
https://www.ncbi.nlm.nih.gov/pubmed/36513073
http://dx.doi.org/10.1016/j.xcrm.2022.100844

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