Non-classical phenotypes of mismatch repair deficiency and microsatellite instability in primary and metastatic tumors at different sites in Lynch syndrome

BACKGROUND: Lynch syndrome is a genetic disease characterized by abnormal DNA replication caused by germline variation in the mismatch repair (MMR) gene. There are rare non-classical phenotypes with loss of MMR protein expression and inconsistent microsatellite stability (MSS) in Lynch syndrome-rela...

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Detalles Bibliográficos
Autores principales: Li, Zhiyu, Cheng, Bo, Liu, Shan, Ding, Shanshan, Liu, Jinhong, Quan, Lanju, Hao, Yanjiao, Xu, Lin, Zhao, Huan, Guo, Jing, Sun, Suozhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797996/
https://www.ncbi.nlm.nih.gov/pubmed/36591511
http://dx.doi.org/10.3389/fonc.2022.1004469

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