Cargando…

Hypoxia-responsive nanomaterials for tumor imaging and therapy

Hypoxia is an important component of tumor microenvironment and plays a pivotal role in cancer progression. With the distinctive physiochemical properties and biological effects, various nanoparticles targeting hypoxia had raised great interest in cancer imaging, drug delivery, and gene therapy duri...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Yifei, Duan, Shao, Han, Chaozhe, Jing, Chengwei, Xiao, Zunyu, Li, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798000/
https://www.ncbi.nlm.nih.gov/pubmed/36591450
http://dx.doi.org/10.3389/fonc.2022.1089446
Descripción
Sumario:Hypoxia is an important component of tumor microenvironment and plays a pivotal role in cancer progression. With the distinctive physiochemical properties and biological effects, various nanoparticles targeting hypoxia had raised great interest in cancer imaging, drug delivery, and gene therapy during the last decade. In the current review, we provided a comprehensive view on the latest progress of novel stimuli-responsive nanomaterials targeting hypoxia-tumor microenvironment (TME), and their applications in cancer diagnosis and therapy. Future prospect and challenges of nanomaterials are also discussed.