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Systematic review reveals sexually antagonistic knockouts in model organisms

Sexual antagonism is thought to be an important selective force in multiple evolutionary processes, but very few examples of the genes involved are known. Such a deficit of loci could partially be explained by the lack of overlap in terminology between scientific disciplines. Following a similar rev...

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Autores principales: Harper, Jon Alexander, Morrow, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798040/
https://www.ncbi.nlm.nih.gov/pubmed/36619711
http://dx.doi.org/10.1002/ece3.9671
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author Harper, Jon Alexander
Morrow, Edward H.
author_facet Harper, Jon Alexander
Morrow, Edward H.
author_sort Harper, Jon Alexander
collection PubMed
description Sexual antagonism is thought to be an important selective force in multiple evolutionary processes, but very few examples of the genes involved are known. Such a deficit of loci could partially be explained by the lack of overlap in terminology between scientific disciplines. Following a similar review in humans, we searched systematically for studies that described genes with sexually antagonistic or sex‐opposite effects in any taxa, using terms designed to capture alternative descriptions of sexual antagonism. Despite drawing on a potentially very large pool of studies we found only eight articles, which between them described seven candidate variants, five of these were gene knockouts. In every case, the variants had net negative effects on the focal trait. One locus was independently validated between studies, but in comparison to previous data on variants in humans and the fruit‐fly, the studies generally suffered from small sample sizes, with concomitant high variance. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss. We searched systematically for genetic variants with sexually antagonistic or sex‐opposite effects in any taxa. Of 2116 articles, we found seven candidate variants, five of which were gene knockouts. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss.
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spelling pubmed-97980402023-01-05 Systematic review reveals sexually antagonistic knockouts in model organisms Harper, Jon Alexander Morrow, Edward H. Ecol Evol Review Articles Sexual antagonism is thought to be an important selective force in multiple evolutionary processes, but very few examples of the genes involved are known. Such a deficit of loci could partially be explained by the lack of overlap in terminology between scientific disciplines. Following a similar review in humans, we searched systematically for studies that described genes with sexually antagonistic or sex‐opposite effects in any taxa, using terms designed to capture alternative descriptions of sexual antagonism. Despite drawing on a potentially very large pool of studies we found only eight articles, which between them described seven candidate variants, five of these were gene knockouts. In every case, the variants had net negative effects on the focal trait. One locus was independently validated between studies, but in comparison to previous data on variants in humans and the fruit‐fly, the studies generally suffered from small sample sizes, with concomitant high variance. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss. We searched systematically for genetic variants with sexually antagonistic or sex‐opposite effects in any taxa. Of 2116 articles, we found seven candidate variants, five of which were gene knockouts. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss. John Wiley and Sons Inc. 2022-12-28 /pmc/articles/PMC9798040/ /pubmed/36619711 http://dx.doi.org/10.1002/ece3.9671 Text en © 2022 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Harper, Jon Alexander
Morrow, Edward H.
Systematic review reveals sexually antagonistic knockouts in model organisms
title Systematic review reveals sexually antagonistic knockouts in model organisms
title_full Systematic review reveals sexually antagonistic knockouts in model organisms
title_fullStr Systematic review reveals sexually antagonistic knockouts in model organisms
title_full_unstemmed Systematic review reveals sexually antagonistic knockouts in model organisms
title_short Systematic review reveals sexually antagonistic knockouts in model organisms
title_sort systematic review reveals sexually antagonistic knockouts in model organisms
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798040/
https://www.ncbi.nlm.nih.gov/pubmed/36619711
http://dx.doi.org/10.1002/ece3.9671
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