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Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training
Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13). Equine athletes may be considered a model for human exercise physiology research, however there is a lack of such studies...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798135/ https://www.ncbi.nlm.nih.gov/pubmed/36618977 http://dx.doi.org/10.1016/j.csbj.2022.12.016 |
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author | Plisak, Urszula Szczepaniak, Jarosław Żmigrodzka, Magdalena Giercuszkiewicz-Hecold, Beata Witkowska-Piłaszewicz, Olga |
author_facet | Plisak, Urszula Szczepaniak, Jarosław Żmigrodzka, Magdalena Giercuszkiewicz-Hecold, Beata Witkowska-Piłaszewicz, Olga |
author_sort | Plisak, Urszula |
collection | PubMed |
description | Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13). Equine athletes may be considered a model for human exercise physiology research, however there is a lack of such studies of this species. Thus, we decided to examine the changes of IL-1ra and IL-13 in serum concentration during aerobic (endurance) and anaerobic (race) exercise in horses of different fitness levels in comparison with the well-known anti-inflammatory cytokine interleukin 10 (IL-10). The group of endurance horses (n = 13) consisted of animals competing over 100 (n = 7) and 120 km (n = 6) rides. The group of racehorses (n = 18) consisted of trained (n = 9) and untrained (n = 9) animals. The blood samples were obtained before and after the exercise. The ELISA test was performed to evaluate the changes of IL-1ra, IL-13 and IL-10 during different types of exercise. In endurance horses there was an increase in IL-13 (p = 0.0012) after the 100 km ride and in IL-1ra (p = 0.0411) after the 120 km ride. In race horses there was a higher IL-13 basal serum concentration in the untrained group, as well as a decrease of IL-13 after exercise (p = 0.0188). In trained racehorses there was an increase in IL-1ra (p < 0.0001) and IL-13 after exercise (p = 0.0028). In conclusion, the reaction of IL-1ra and IL-13 to different types of exercise differ from each other. Thus, in future, they may be helpful in monitoring the fitness of horses, however more research is needed. |
format | Online Article Text |
id | pubmed-9798135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-97981352023-01-05 Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training Plisak, Urszula Szczepaniak, Jarosław Żmigrodzka, Magdalena Giercuszkiewicz-Hecold, Beata Witkowska-Piłaszewicz, Olga Comput Struct Biotechnol J Research Article Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13). Equine athletes may be considered a model for human exercise physiology research, however there is a lack of such studies of this species. Thus, we decided to examine the changes of IL-1ra and IL-13 in serum concentration during aerobic (endurance) and anaerobic (race) exercise in horses of different fitness levels in comparison with the well-known anti-inflammatory cytokine interleukin 10 (IL-10). The group of endurance horses (n = 13) consisted of animals competing over 100 (n = 7) and 120 km (n = 6) rides. The group of racehorses (n = 18) consisted of trained (n = 9) and untrained (n = 9) animals. The blood samples were obtained before and after the exercise. The ELISA test was performed to evaluate the changes of IL-1ra, IL-13 and IL-10 during different types of exercise. In endurance horses there was an increase in IL-13 (p = 0.0012) after the 100 km ride and in IL-1ra (p = 0.0411) after the 120 km ride. In race horses there was a higher IL-13 basal serum concentration in the untrained group, as well as a decrease of IL-13 after exercise (p = 0.0188). In trained racehorses there was an increase in IL-1ra (p < 0.0001) and IL-13 after exercise (p = 0.0028). In conclusion, the reaction of IL-1ra and IL-13 to different types of exercise differ from each other. Thus, in future, they may be helpful in monitoring the fitness of horses, however more research is needed. Research Network of Computational and Structural Biotechnology 2022-12-13 /pmc/articles/PMC9798135/ /pubmed/36618977 http://dx.doi.org/10.1016/j.csbj.2022.12.016 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Plisak, Urszula Szczepaniak, Jarosław Żmigrodzka, Magdalena Giercuszkiewicz-Hecold, Beata Witkowska-Piłaszewicz, Olga Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title | Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title_full | Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title_fullStr | Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title_full_unstemmed | Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title_short | Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
title_sort | changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798135/ https://www.ncbi.nlm.nih.gov/pubmed/36618977 http://dx.doi.org/10.1016/j.csbj.2022.12.016 |
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