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Crystal-storing histiocytosis in the stomach: A case report and review of the literature
Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of non-neoplastic histiocytes that contain intracytoplasmic crystallized immunoglobulins. Although CSH can occur in various organs, gastric CSH is very rare. Therefore, diagnosing gastric CSH remains a challenge...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798227/ https://www.ncbi.nlm.nih.gov/pubmed/36591494 http://dx.doi.org/10.3389/fonc.2022.1024971 |
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author | Kong, Linghong Xue, Liyan Zhong, Yanfeng Wang, Shenglan Zheng, Danfeng Wang, Lining Jiao, Yang Zhang, Xinpeng Xue, Huizhong Liu, Xiaogang |
author_facet | Kong, Linghong Xue, Liyan Zhong, Yanfeng Wang, Shenglan Zheng, Danfeng Wang, Lining Jiao, Yang Zhang, Xinpeng Xue, Huizhong Liu, Xiaogang |
author_sort | Kong, Linghong |
collection | PubMed |
description | Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of non-neoplastic histiocytes that contain intracytoplasmic crystallized immunoglobulins. Although CSH can occur in various organs, gastric CSH is very rare. Therefore, diagnosing gastric CSH remains a challenge. Here, we present the case of a 69-year-old man with localized gastric CSH who presented with positive fecal occult blood for 2 days. Gastroscopy showed that there was a piece of irregular whitish focus in the big bend of the gastric antrum, which was soft and elastic. Histologically, the biopsied gastric mucosa showed chronic inflammation, mild activity with erosion, and numerous eosinophilic mononuclear cells containing fibrillary crystalloid inclusions in the lamina propria. Immunohistochemically, these crystal-containing cells were positive for CD68/PGM1 and Igk, which revealed that the cells were histiocytes harboring kappa light chain-restricted immunoglobulin crystals. Electron microscopic examination showed numerous high-electron-density particles in the cytoplasm of cells, with crystal structures of different sizes and shapes. This case highlights how immunohistochemistry can help with differential diagnosis and classification. |
format | Online Article Text |
id | pubmed-9798227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97982272022-12-30 Crystal-storing histiocytosis in the stomach: A case report and review of the literature Kong, Linghong Xue, Liyan Zhong, Yanfeng Wang, Shenglan Zheng, Danfeng Wang, Lining Jiao, Yang Zhang, Xinpeng Xue, Huizhong Liu, Xiaogang Front Oncol Oncology Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of non-neoplastic histiocytes that contain intracytoplasmic crystallized immunoglobulins. Although CSH can occur in various organs, gastric CSH is very rare. Therefore, diagnosing gastric CSH remains a challenge. Here, we present the case of a 69-year-old man with localized gastric CSH who presented with positive fecal occult blood for 2 days. Gastroscopy showed that there was a piece of irregular whitish focus in the big bend of the gastric antrum, which was soft and elastic. Histologically, the biopsied gastric mucosa showed chronic inflammation, mild activity with erosion, and numerous eosinophilic mononuclear cells containing fibrillary crystalloid inclusions in the lamina propria. Immunohistochemically, these crystal-containing cells were positive for CD68/PGM1 and Igk, which revealed that the cells were histiocytes harboring kappa light chain-restricted immunoglobulin crystals. Electron microscopic examination showed numerous high-electron-density particles in the cytoplasm of cells, with crystal structures of different sizes and shapes. This case highlights how immunohistochemistry can help with differential diagnosis and classification. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9798227/ /pubmed/36591494 http://dx.doi.org/10.3389/fonc.2022.1024971 Text en Copyright © 2022 Kong, Xue, Zhong, Wang, Zheng, Wang, Jiao, Zhang, Xue and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Kong, Linghong Xue, Liyan Zhong, Yanfeng Wang, Shenglan Zheng, Danfeng Wang, Lining Jiao, Yang Zhang, Xinpeng Xue, Huizhong Liu, Xiaogang Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title | Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title_full | Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title_fullStr | Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title_full_unstemmed | Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title_short | Crystal-storing histiocytosis in the stomach: A case report and review of the literature |
title_sort | crystal-storing histiocytosis in the stomach: a case report and review of the literature |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798227/ https://www.ncbi.nlm.nih.gov/pubmed/36591494 http://dx.doi.org/10.3389/fonc.2022.1024971 |
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