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Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis
In this manuscript, we report torque teno mini virus (TTMV) as a cause of acute promyelocytic leukemia (APL) lacking PML::RARA in a 3-year-old boy. Astolfi et al. firstly identified partial integration of the TTMV genome into RARA intron 2, which resulted in in-frame TTMV::RARA fusion in two APL-lik...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798314/ https://www.ncbi.nlm.nih.gov/pubmed/36591487 http://dx.doi.org/10.3389/fonc.2022.1074913 |
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author | Chen, Xue Wang, Fang Zhou, Xiaosu Zhang, Yang Cao, Panxiang Ma, Xiaoli Yuan, Lili Fang, Jiancheng Liu, Mingyue Liu, Ming Chen, Jiaqi Chen, Qihui Wu, Ping Lu, Yue Ma, Xiujuan Liu, Hongxing |
author_facet | Chen, Xue Wang, Fang Zhou, Xiaosu Zhang, Yang Cao, Panxiang Ma, Xiaoli Yuan, Lili Fang, Jiancheng Liu, Mingyue Liu, Ming Chen, Jiaqi Chen, Qihui Wu, Ping Lu, Yue Ma, Xiujuan Liu, Hongxing |
author_sort | Chen, Xue |
collection | PubMed |
description | In this manuscript, we report torque teno mini virus (TTMV) as a cause of acute promyelocytic leukemia (APL) lacking PML::RARA in a 3-year-old boy. Astolfi et al. firstly identified partial integration of the TTMV genome into RARA intron 2, which resulted in in-frame TTMV::RARA fusion in two APL-like pediatric cases without PML::RARA in November 2021. This fascinating report identified an unexpected exogenous genetic cause of APL and could be of great importance for diagnosing and managing APL. Here we report the third childhood APL-like case caused by TTMV integration and investigate the location and structure of the integrated TTMV sequence. These findings suggest TTMV::RARA is a recurrent cause of APL lacking PML::RARA. Considering the widespread prevalence of TTMV in the population, more TTMV::RARA positive APL-like cases might remain to be identified. Establishing a bioinformatic analysis strategy optimized for the highly variable TTMV genome sequence may facilitate the identification of TTMV::RARA by whole transcript sequencing. An effective PCR protocol to identify TTMV::RARA based on a profound analysis of the conservation of TTMV segments in the fusion transcript is also expected. Also, further investigation is needed to elucidate the oncogenic mechanisms of TTMV integration and the clinical features of TTMV::RARA positive patients. |
format | Online Article Text |
id | pubmed-9798314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97983142022-12-30 Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis Chen, Xue Wang, Fang Zhou, Xiaosu Zhang, Yang Cao, Panxiang Ma, Xiaoli Yuan, Lili Fang, Jiancheng Liu, Mingyue Liu, Ming Chen, Jiaqi Chen, Qihui Wu, Ping Lu, Yue Ma, Xiujuan Liu, Hongxing Front Oncol Oncology In this manuscript, we report torque teno mini virus (TTMV) as a cause of acute promyelocytic leukemia (APL) lacking PML::RARA in a 3-year-old boy. Astolfi et al. firstly identified partial integration of the TTMV genome into RARA intron 2, which resulted in in-frame TTMV::RARA fusion in two APL-like pediatric cases without PML::RARA in November 2021. This fascinating report identified an unexpected exogenous genetic cause of APL and could be of great importance for diagnosing and managing APL. Here we report the third childhood APL-like case caused by TTMV integration and investigate the location and structure of the integrated TTMV sequence. These findings suggest TTMV::RARA is a recurrent cause of APL lacking PML::RARA. Considering the widespread prevalence of TTMV in the population, more TTMV::RARA positive APL-like cases might remain to be identified. Establishing a bioinformatic analysis strategy optimized for the highly variable TTMV genome sequence may facilitate the identification of TTMV::RARA by whole transcript sequencing. An effective PCR protocol to identify TTMV::RARA based on a profound analysis of the conservation of TTMV segments in the fusion transcript is also expected. Also, further investigation is needed to elucidate the oncogenic mechanisms of TTMV integration and the clinical features of TTMV::RARA positive patients. Frontiers Media S.A. 2022-12-15 /pmc/articles/PMC9798314/ /pubmed/36591487 http://dx.doi.org/10.3389/fonc.2022.1074913 Text en Copyright © 2022 Chen, Wang, Zhou, Zhang, Cao, Ma, Yuan, Fang, Liu, Liu, Chen, Chen, Wu, Lu, Ma and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Xue Wang, Fang Zhou, Xiaosu Zhang, Yang Cao, Panxiang Ma, Xiaoli Yuan, Lili Fang, Jiancheng Liu, Mingyue Liu, Ming Chen, Jiaqi Chen, Qihui Wu, Ping Lu, Yue Ma, Xiujuan Liu, Hongxing Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title | Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title_full | Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title_fullStr | Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title_full_unstemmed | Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title_short | Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis |
title_sort | torque teno mini virus driven childhood acute promyelocytic leukemia: the third case report and sequence analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798314/ https://www.ncbi.nlm.nih.gov/pubmed/36591487 http://dx.doi.org/10.3389/fonc.2022.1074913 |
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