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Small-molecule compound from AlphaScreen disrupts tau-glycan interface

Tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. Tau aggregates can propagate from one neuron to another in a prion-like manner, mediated by the interaction between tau and cell surface heparan sulfate proteoglycans. We developed an AlphaS...

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Detalles Bibliográficos
Autores principales:	Faris, Shannon, Jin, Weihua, Gibson, James, Murray, Anqesha, Smith, Nathan, He, Peng, Zhang, Fuming, Linhardt, Robert, Wang, Chunyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798536/ https://www.ncbi.nlm.nih.gov/pubmed/36589242 http://dx.doi.org/10.3389/fmolb.2022.1083225

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