Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

BACKGROUND: Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inflammasome inhibitors targeting NOD-like receptor protein 3 (NLRP3) have been designed and developed, none of the inhibitors a...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Zhou, YuWei, Ning, XinPeng, Li, ShengLong, Xue, DongDong, Wei, CaiLv, Zhu, Zhu, Sheng, LongXiang, Lu, BingZheng, Li, Yuan, Ye, XiaoYuan, Fu, YunZhao, Bai, Chuan, Cai, Wei, Ding, YuXuan, Lin, SuiZhen, Yan, GuangMei, Huang, YiJun, Yin, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798610/
https://www.ncbi.nlm.nih.gov/pubmed/36577999
http://dx.doi.org/10.1186/s12974-022-02682-w

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