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A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study

BACKGROUND: The injection activity of tracer, acquisition time, patient-specific photon attenuation, and large body mass, can influence on image quality. Fixed acquisition time and body mass related injection activity in clinical practice results in a large difference in image quality. Thus, this st...

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Autores principales: Xiao, Jie, Yu, Haojun, Sui, Xiuli, Liu, Guobing, Cao, Yanyan, Yanzhao, Zhao, Zhang, Yiqiu, Hu, Pengcheng, Cheng, Dengfeng, Shi, Hongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798642/
https://www.ncbi.nlm.nih.gov/pubmed/36578034
http://dx.doi.org/10.1186/s40644-022-00517-8
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author Xiao, Jie
Yu, Haojun
Sui, Xiuli
Liu, Guobing
Cao, Yanyan
Yanzhao, Zhao
Zhang, Yiqiu
Hu, Pengcheng
Cheng, Dengfeng
Shi, Hongcheng
author_facet Xiao, Jie
Yu, Haojun
Sui, Xiuli
Liu, Guobing
Cao, Yanyan
Yanzhao, Zhao
Zhang, Yiqiu
Hu, Pengcheng
Cheng, Dengfeng
Shi, Hongcheng
author_sort Xiao, Jie
collection PubMed
description BACKGROUND: The injection activity of tracer, acquisition time, patient-specific photon attenuation, and large body mass, can influence on image quality. Fixed acquisition time and body mass related injection activity in clinical practice results in a large difference in image quality. Thus, this study proposes a patient-specific acquisition time regimen of (68) Ga-DOTATATE total-body positron emission tomography-computed tomography (PET/CT) to counteract the influence of body mass (BM, kg) on image quality, and acquire an acceptable and constant image of patients with neuroendocrine tumors (NETs). METHODS: The development cohort consisting of 19 consecutive patients with full activity (88.7–204.9 MBq, 2.0 ± 0.1 MBq/kg) was to establish the acquisition time regimen. The liver SNR (signal-to-noise ratio, SNR(L)) was normalized (SNR(norm)) by the product of injected activity (MBq) and acquisition time (min). Fitting of SNR(norm) against body mass (BM, kg) in linear correlation was performed. Subjective assessment of image quality was performed using a 5-point Likert scale to determine the acceptable threshold of SNR(L), and an optimized acquisition regimen based on BM was proposed, and validated its feasibility through the validation cohort of 57 consecutive NET patients with half activity (66.9 ± 11.3 MBq, 1.0 ± 0.1 MBq/kg) and a fixed acquisition time regimen. RESULTS: The linear correlation (R(2) = 0.63) between SNR(norm) and BM (kg) was SNR(norm) = -0.01*BM + 1.50. The threshold SNR(L) of acceptable image quality was 11.2. The patient-specific variable acquisition time regimen was determined as: t (min) = 125.4/(injective activity)*(-0.01*BM + 1.50)(2). Based on that proposed regimen, the average acquisition time for acceptable image quality in the validation cohort was 2.99 ± 0.91 min, ranging from 2.18 to 6.35 min, which was reduced by 36.50% ~ 78.20% compared with the fixed acquisition time of 10 min. Subjective evaluation showed that acceptable image quality could be obtained at 3.00 min in the validation group, with an average subjective score of 3.44 ± 0.53 (kappa = 0.97, 95% CI: 0.96 ~ 0.98). Bland–Altman analysis revealed good agreement between the proposed regimen and the fixed acquisition time cohort. CONCLUSION: A patient-specific acquisition time regimen was proposed in NET patients in development cohort and validated its feasibility in patients with NETs in validation cohort by (68) Ga-DOTATATE total-body PET/CT imaging. Based on the proposed regimen, the homogenous image quality with optimal acquisition time was available independent of body mass. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00517-8.
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spelling pubmed-97986422022-12-30 A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study Xiao, Jie Yu, Haojun Sui, Xiuli Liu, Guobing Cao, Yanyan Yanzhao, Zhao Zhang, Yiqiu Hu, Pengcheng Cheng, Dengfeng Shi, Hongcheng Cancer Imaging Research Article BACKGROUND: The injection activity of tracer, acquisition time, patient-specific photon attenuation, and large body mass, can influence on image quality. Fixed acquisition time and body mass related injection activity in clinical practice results in a large difference in image quality. Thus, this study proposes a patient-specific acquisition time regimen of (68) Ga-DOTATATE total-body positron emission tomography-computed tomography (PET/CT) to counteract the influence of body mass (BM, kg) on image quality, and acquire an acceptable and constant image of patients with neuroendocrine tumors (NETs). METHODS: The development cohort consisting of 19 consecutive patients with full activity (88.7–204.9 MBq, 2.0 ± 0.1 MBq/kg) was to establish the acquisition time regimen. The liver SNR (signal-to-noise ratio, SNR(L)) was normalized (SNR(norm)) by the product of injected activity (MBq) and acquisition time (min). Fitting of SNR(norm) against body mass (BM, kg) in linear correlation was performed. Subjective assessment of image quality was performed using a 5-point Likert scale to determine the acceptable threshold of SNR(L), and an optimized acquisition regimen based on BM was proposed, and validated its feasibility through the validation cohort of 57 consecutive NET patients with half activity (66.9 ± 11.3 MBq, 1.0 ± 0.1 MBq/kg) and a fixed acquisition time regimen. RESULTS: The linear correlation (R(2) = 0.63) between SNR(norm) and BM (kg) was SNR(norm) = -0.01*BM + 1.50. The threshold SNR(L) of acceptable image quality was 11.2. The patient-specific variable acquisition time regimen was determined as: t (min) = 125.4/(injective activity)*(-0.01*BM + 1.50)(2). Based on that proposed regimen, the average acquisition time for acceptable image quality in the validation cohort was 2.99 ± 0.91 min, ranging from 2.18 to 6.35 min, which was reduced by 36.50% ~ 78.20% compared with the fixed acquisition time of 10 min. Subjective evaluation showed that acceptable image quality could be obtained at 3.00 min in the validation group, with an average subjective score of 3.44 ± 0.53 (kappa = 0.97, 95% CI: 0.96 ~ 0.98). Bland–Altman analysis revealed good agreement between the proposed regimen and the fixed acquisition time cohort. CONCLUSION: A patient-specific acquisition time regimen was proposed in NET patients in development cohort and validated its feasibility in patients with NETs in validation cohort by (68) Ga-DOTATATE total-body PET/CT imaging. Based on the proposed regimen, the homogenous image quality with optimal acquisition time was available independent of body mass. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00517-8. BioMed Central 2022-12-29 /pmc/articles/PMC9798642/ /pubmed/36578034 http://dx.doi.org/10.1186/s40644-022-00517-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Xiao, Jie
Yu, Haojun
Sui, Xiuli
Liu, Guobing
Cao, Yanyan
Yanzhao, Zhao
Zhang, Yiqiu
Hu, Pengcheng
Cheng, Dengfeng
Shi, Hongcheng
A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title_full A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title_fullStr A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title_full_unstemmed A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title_short A personal acquisition time regimen of (68)Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
title_sort personal acquisition time regimen of (68)ga-dotatate total-body pet/ct in patients with neuroendocrine tumor (net): a feasibility study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798642/
https://www.ncbi.nlm.nih.gov/pubmed/36578034
http://dx.doi.org/10.1186/s40644-022-00517-8
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