Synthesis of Unsymmetrical Ketones Using Chelation-Controlled Sequential Substitution of N-Triazinylamide/Weinreb Amide by Organometallic Reagents

[Image: see text] N-(2,4-Dimethoxy-1,3,5-triazinyl)amide was found to exhibit similar behavior to N-methoxy-N-methylamide (Weinreb amide) but higher reactivity for nucleophilic substitution by organometallic reagents. Triazinylamide suppresses overaddition, leading to the formation of a tertiary alc...

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Detalles Bibliográficos
Autores principales: Hirao, Shotaro, Saeki, Rumi, Takahashi, Toru, Iwai, Kento, Nishiwaki, Nagatoshi, Ohga, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798741/
https://www.ncbi.nlm.nih.gov/pubmed/36591189
http://dx.doi.org/10.1021/acsomega.2c06756

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