Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents

[Image: see text] Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the...

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Autores principales: Aires, Antonio, Fernández-Afonso, Yilian, Guedes, Gabriela, Guisasola, Eduardo, Gutiérrez, Lucía, Cortajarena, Aitziber L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798829/
https://www.ncbi.nlm.nih.gov/pubmed/36590706
http://dx.doi.org/10.1021/acs.chemmater.2c01746
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author Aires, Antonio
Fernández-Afonso, Yilian
Guedes, Gabriela
Guisasola, Eduardo
Gutiérrez, Lucía
Cortajarena, Aitziber L.
author_facet Aires, Antonio
Fernández-Afonso, Yilian
Guedes, Gabriela
Guisasola, Eduardo
Gutiérrez, Lucía
Cortajarena, Aitziber L.
author_sort Aires, Antonio
collection PubMed
description [Image: see text] Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications.
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spelling pubmed-97988292022-12-30 Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents Aires, Antonio Fernández-Afonso, Yilian Guedes, Gabriela Guisasola, Eduardo Gutiérrez, Lucía Cortajarena, Aitziber L. Chem Mater [Image: see text] Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because of their biocompatibility and physicochemical properties. This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall IONPs. Rationally designed proteins, containing different number of metal-coordination sites, were evaluated to control the size and the physicochemical and magnetic properties of a set of protein-stabilized IONPs (Prot-IONPs). Prot-IONPs, synthesized through an optimized coprecipitation approach, presented good T1 and T2 relaxivity values, stability, and biocompatibility, showing potential for magnetic resonance imaging (MRI) applications. American Chemical Society 2022-12-02 2022-12-27 /pmc/articles/PMC9798829/ /pubmed/36590706 http://dx.doi.org/10.1021/acs.chemmater.2c01746 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Aires, Antonio
Fernández-Afonso, Yilian
Guedes, Gabriela
Guisasola, Eduardo
Gutiérrez, Lucía
Cortajarena, Aitziber L.
Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title_full Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title_fullStr Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title_full_unstemmed Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title_short Engineered Protein-Driven Synthesis of Tunable Iron Oxide Nanoparticles as T1 and T2 Magnetic Resonance Imaging Contrast Agents
title_sort engineered protein-driven synthesis of tunable iron oxide nanoparticles as t1 and t2 magnetic resonance imaging contrast agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798829/
https://www.ncbi.nlm.nih.gov/pubmed/36590706
http://dx.doi.org/10.1021/acs.chemmater.2c01746
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