Cargando…
Histone Modifications in Acute Kidney Injury
BACKGROUND: Acute kidney injury (AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. SUMMARY: There...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798838/ https://www.ncbi.nlm.nih.gov/pubmed/36590679 http://dx.doi.org/10.1159/000527799 |
_version_ | 1784860990447288320 |
---|---|
author | Wang, Jun Shen, Fengchen Liu, Feng Zhuang, Shougang |
author_facet | Wang, Jun Shen, Fengchen Liu, Feng Zhuang, Shougang |
author_sort | Wang, Jun |
collection | PubMed |
description | BACKGROUND: Acute kidney injury (AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. SUMMARY: There are several types of histone modification, including methylation, acetylation, phosphorylation, crotonylation, citrullination, and sumoylation. Histone modifications are associated with the transcription of many genes and activation of multiple signaling pathways that contribute to the pathogenesis of AKI. Thus, targeting histone modification may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery. In this review, we summarize recent advances on the modification, regulation, and implication of histone modifications in AKI. KEY MESSAGES: Histone modifications contribute to the pathogenesis of AKI. Understanding of epigenetic regulation in AKI will aid in establishing the utility of pharmacologic targeting of histone modification as a potential novel therapy for AKI. |
format | Online Article Text |
id | pubmed-9798838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-97988382022-12-30 Histone Modifications in Acute Kidney Injury Wang, Jun Shen, Fengchen Liu, Feng Zhuang, Shougang Kidney Dis (Basel) Review Article BACKGROUND: Acute kidney injury (AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. SUMMARY: There are several types of histone modification, including methylation, acetylation, phosphorylation, crotonylation, citrullination, and sumoylation. Histone modifications are associated with the transcription of many genes and activation of multiple signaling pathways that contribute to the pathogenesis of AKI. Thus, targeting histone modification may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery. In this review, we summarize recent advances on the modification, regulation, and implication of histone modifications in AKI. KEY MESSAGES: Histone modifications contribute to the pathogenesis of AKI. Understanding of epigenetic regulation in AKI will aid in establishing the utility of pharmacologic targeting of histone modification as a potential novel therapy for AKI. S. Karger AG 2022-11-10 /pmc/articles/PMC9798838/ /pubmed/36590679 http://dx.doi.org/10.1159/000527799 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Review Article Wang, Jun Shen, Fengchen Liu, Feng Zhuang, Shougang Histone Modifications in Acute Kidney Injury |
title | Histone Modifications in Acute Kidney Injury |
title_full | Histone Modifications in Acute Kidney Injury |
title_fullStr | Histone Modifications in Acute Kidney Injury |
title_full_unstemmed | Histone Modifications in Acute Kidney Injury |
title_short | Histone Modifications in Acute Kidney Injury |
title_sort | histone modifications in acute kidney injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798838/ https://www.ncbi.nlm.nih.gov/pubmed/36590679 http://dx.doi.org/10.1159/000527799 |
work_keys_str_mv | AT wangjun histonemodificationsinacutekidneyinjury AT shenfengchen histonemodificationsinacutekidneyinjury AT liufeng histonemodificationsinacutekidneyinjury AT zhuangshougang histonemodificationsinacutekidneyinjury |