Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion

[Image: see text] Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several challenges remain before this approach can offer broad clinical translation of mRNA therapeutics. To improve their efficacy, a better understanding is required regarding how LNPs are trapped a...

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Detalles Bibliográficos
Autores principales: Aliakbarinodehi, Nima, Gallud, Audrey, Mapar, Mokhtar, Wesén, Emelie, Heydari, Sahar, Jing, Yujia, Emilsson, Gustav, Liu, Kai, Sabirsh, Alan, Zhdanov, Vladimir P., Lindfors, Lennart, Esbjörner, Elin K., Höök, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798854/
https://www.ncbi.nlm.nih.gov/pubmed/36511601
http://dx.doi.org/10.1021/acsnano.2c04829

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