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Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immunity at the respiratory mucosa. We developed a vaccine strateg...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798903/ https://www.ncbi.nlm.nih.gov/pubmed/36302057 http://dx.doi.org/10.1126/science.abo2523 |
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author | Mao, Tianyang Israelow, Benjamin Peña-Hernández, Mario A. Suberi, Alexandra Zhou, Liqun Luyten, Sophia Reschke, Melanie Dong, Huiping Homer, Robert J. Saltzman, W. Mark Iwasaki, Akiko |
author_facet | Mao, Tianyang Israelow, Benjamin Peña-Hernández, Mario A. Suberi, Alexandra Zhou, Liqun Luyten, Sophia Reschke, Melanie Dong, Huiping Homer, Robert J. Saltzman, W. Mark Iwasaki, Akiko |
author_sort | Mao, Tianyang |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immunity at the respiratory mucosa. We developed a vaccine strategy that we call “prime and spike,” which leverages existing immunity generated by primary vaccination (prime) to elicit mucosal immune memory within the respiratory tract by using unadjuvanted intranasal spike boosters (spike). We show that prime and spike induces robust resident memory B and T cell responses, induces immunoglobulin A at the respiratory mucosa, boosts systemic immunity, and completely protects mice with partial immunity from lethal SARS-CoV-2 infection. Using divergent spike proteins, prime and spike enables the induction of cross-reactive immunity against sarbecoviruses. |
format | Online Article Text |
id | pubmed-9798903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-97989032023-01-06 Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses Mao, Tianyang Israelow, Benjamin Peña-Hernández, Mario A. Suberi, Alexandra Zhou, Liqun Luyten, Sophia Reschke, Melanie Dong, Huiping Homer, Robert J. Saltzman, W. Mark Iwasaki, Akiko Science Research Articles The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immunity at the respiratory mucosa. We developed a vaccine strategy that we call “prime and spike,” which leverages existing immunity generated by primary vaccination (prime) to elicit mucosal immune memory within the respiratory tract by using unadjuvanted intranasal spike boosters (spike). We show that prime and spike induces robust resident memory B and T cell responses, induces immunoglobulin A at the respiratory mucosa, boosts systemic immunity, and completely protects mice with partial immunity from lethal SARS-CoV-2 infection. Using divergent spike proteins, prime and spike enables the induction of cross-reactive immunity against sarbecoviruses. American Association for the Advancement of Science 2022-11-25 /pmc/articles/PMC9798903/ /pubmed/36302057 http://dx.doi.org/10.1126/science.abo2523 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Mao, Tianyang Israelow, Benjamin Peña-Hernández, Mario A. Suberi, Alexandra Zhou, Liqun Luyten, Sophia Reschke, Melanie Dong, Huiping Homer, Robert J. Saltzman, W. Mark Iwasaki, Akiko Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title | Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title_full | Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title_fullStr | Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title_full_unstemmed | Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title_short | Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
title_sort | unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798903/ https://www.ncbi.nlm.nih.gov/pubmed/36302057 http://dx.doi.org/10.1126/science.abo2523 |
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