Cargando…

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a multiomic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. We combined metabolomics, CRISPR screening, and transcriptomic data across more than 700 solid tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olsen, Thale Kristin, Dyberg, Cecilia, Embaie, Bethel Tesfai, Alchahin, Adele, Milosevic, Jelena, Ding, Jane, Otte, Jörg, Tümmler, Conny, Hed Myrberg, Ida, Westerhout, Ellen M., Koster, Jan, Versteeg, Rogier, Ding, Han-Fei, Kogner, Per, Johnsen, John Inge, Sykes, David B., Baryawno, Ninib
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798925/ https://www.ncbi.nlm.nih.gov/pubmed/35943801 http://dx.doi.org/10.1172/jci.insight.153836

Ejemplares similares

Recent Advances in Single-Cell RNA-Sequencing of Primary and Metastatic Clear Cell Renal Cell Carcinoma
por: Alchahin, Adele M., et al.
Publicado: (2023)

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
por: Wickström, Malin, et al.
Publicado: (2015)

The immune cell atlas of human neuroblastoma
por: Verhoeven, Bronte Manouk, et al.
Publicado: (2022)

High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice
por: Milosevic, Jelena, et al.
Publicado: (2021)

MDB-04. SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
por: Ruchiy, Yana, et al.
Publicado: (2023)

Is human cytomegalovirus a target in cancer therapy?
por: Johnsen, John Inge, et al.
Publicado: (2011)

Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth
por: Dyberg, Cecilia, et al.
Publicado: (2019)

MYCN Function in Neuroblastoma Development
por: Otte, Jörg, et al.
Publicado: (2021)

DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia
por: Sexauer, Amy N., et al.
Publicado: (2023)

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells In Vitro
por: Tümmler, Conny, et al.
Publicado: (2019)

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma
por: Dyberg, Cecilia, et al.
Publicado: (2016)

DHODH and cancer: promising prospects to be explored
por: Zhou, Yue, et al.
Publicado: (2021)

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
por: Kameneva, Polina, et al.
Publicado: (2021)

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
por: Alchahin, Adele M., et al.
Publicado: (2022)

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
por: Tümmler, Conny, et al.
Publicado: (2017)

DHODH tangoing with GPX4 on the ferroptotic stage
por: Wang, Fudi, et al.
Publicado: (2021)

Neuroblastoma—A Neural Crest Derived Embryonal Malignancy
por: Johnsen, John Inge, et al.
Publicado: (2019)

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy
por: Lamers, Fieke, et al.
Publicado: (2012)

The Warburg effect modulates DHODH role in ferroptosis: a review
por: Amos, Alvan, et al.
Publicado: (2023)

Depression among Parents Two to Six Years Following the Loss of a Child by Suicide: A Novel Prediction Model
por: Nyberg, Tommy, et al.
Publicado: (2016)

Profile of macular ganglion cell-inner plexiform layer thickness in healthy 6.5 year- old Swedish children
por: Arnljots, Urszula, et al.
Publicado: (2020)

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
por: Mullen, Nicholas J., et al.
Publicado: (2023)

Integrative discovery of treatments for high-risk neuroblastoma
por: Almstedt, Elin, et al.
Publicado: (2020)

Genetic Sequence Variants in TLR4, MBL or IL-1 Receptor Antagonist is not Associated to Increased Risk for Febrile Neutropenia in Children with ALL
por: Wahlund, Martina, et al.
Publicado: (2020)

Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
por: Sender, Vicky, et al.
Publicado: (2020)

Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
por: Valind, Anders, et al.
Publicado: (2023)

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments
por: Petukhov, Viktor, et al.
Publicado: (2018)

Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma
por: Liu, Lichao, et al.
Publicado: (2017)

The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
por: Gaidano, Valentina, et al.
Publicado: (2021)

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
por: Zhang, Juan, et al.
Publicado: (2021)

Optical Coherence Tomography Identifies Visual Pathway Involvement Earlier than Visual Function Tests in Children with MRI-Verified Optic Pathway Gliomas
por: Arnljots, Urszula, et al.
Publicado: (2022)

Time trends in occupational exposure to chemicals in Sweden: proportion exposed, distribution across demographic and labor market strata, and exposure levels
por: Gustavsson, Per, et al.
Publicado: (2022)

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition
por: Bate-Eya, Laurel T., et al.
Publicado: (2016)

Babesia bovis Dihydroorotate Dehydrogenase (BboDHODH) is a Novel Molecular Target of Drug for Bovine Babesiosis
por: KAMYINGKIRD, Ketsarin, et al.
Publicado: (2013)

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
por: Ladds, Marcus J. G.W., et al.
Publicado: (2021)

Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review
por: Kaur, Hardeep, et al.
Publicado: (2021)

The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis
por: Sibille, Giulia, et al.
Publicado: (2022)

Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species
por: Pinder, Corinne, et al.
Publicado: (2023)

Assessment of a novel variation in DHODH gene causing Miller syndrome: The first report in Chinese population
por: Yang, Kai, et al.
Publicado: (2023)

Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma
por: Qian, Yu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0fdli4ghe9923cev8ijf3il85f