Cargando…
A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022)
Germline‐Specific Mitochondrial Fusion Regulator In article number 2203631 by Zhen‐Xia Chen, Yonghua Sun, and co‐workers, a novel germline‐specific gene, pld6, encoding a mitochondrial fusion regulator (tool in the hands of Da Yu from an ancient Chinese legend, Da Yu Controlling the Floods), was ide...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798994/ http://dx.doi.org/10.1002/advs.202270233 |
_version_ | 1784861023313854464 |
---|---|
author | Zhang, Ru Tu, Yi‐Xuan Ye, Ding Gu, Zhenglong Chen, Zhen‐Xia Sun, Yonghua |
author_facet | Zhang, Ru Tu, Yi‐Xuan Ye, Ding Gu, Zhenglong Chen, Zhen‐Xia Sun, Yonghua |
author_sort | Zhang, Ru |
collection | PubMed |
description | Germline‐Specific Mitochondrial Fusion Regulator In article number 2203631 by Zhen‐Xia Chen, Yonghua Sun, and co‐workers, a novel germline‐specific gene, pld6, encoding a mitochondrial fusion regulator (tool in the hands of Da Yu from an ancient Chinese legend, Da Yu Controlling the Floods), was identified in zebrafish. Further gene knockout study highlights the essential role of Pld6‐mediated mitochondrial dynamics in the maintenance and differentiation of germline stem and progenitor cells (GSPCs), as well as in gonadal development and gametogenesis. [Image: see text] |
format | Online Article Text |
id | pubmed-9798994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97989942023-01-05 A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) Zhang, Ru Tu, Yi‐Xuan Ye, Ding Gu, Zhenglong Chen, Zhen‐Xia Sun, Yonghua Adv Sci (Weinh) Back Cover Germline‐Specific Mitochondrial Fusion Regulator In article number 2203631 by Zhen‐Xia Chen, Yonghua Sun, and co‐workers, a novel germline‐specific gene, pld6, encoding a mitochondrial fusion regulator (tool in the hands of Da Yu from an ancient Chinese legend, Da Yu Controlling the Floods), was identified in zebrafish. Further gene knockout study highlights the essential role of Pld6‐mediated mitochondrial dynamics in the maintenance and differentiation of germline stem and progenitor cells (GSPCs), as well as in gonadal development and gametogenesis. [Image: see text] John Wiley and Sons Inc. 2022-12-29 /pmc/articles/PMC9798994/ http://dx.doi.org/10.1002/advs.202270233 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Back Cover Zhang, Ru Tu, Yi‐Xuan Ye, Ding Gu, Zhenglong Chen, Zhen‐Xia Sun, Yonghua A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title | A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title_full | A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title_fullStr | A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title_full_unstemmed | A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title_short | A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells (Adv. Sci. 36/2022) |
title_sort | germline‐specific regulator of mitochondrial fusion is required for maintenance and differentiation of germline stem and progenitor cells (adv. sci. 36/2022) |
topic | Back Cover |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798994/ http://dx.doi.org/10.1002/advs.202270233 |
work_keys_str_mv | AT zhangru agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT tuyixuan agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT yeding agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT guzhenglong agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT chenzhenxia agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT sunyonghua agermlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT zhangru germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT tuyixuan germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT yeding germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT guzhenglong germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT chenzhenxia germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 AT sunyonghua germlinespecificregulatorofmitochondrialfusionisrequiredformaintenanceanddifferentiationofgermlinestemandprogenitorcellsadvsci362022 |