Human induced pluripotent stem cells generated from STING-associated vasculopathy with onset in infancy (SAVI) patients with a heterozygous mutation in the STING gene

We have successfully created induced pluripotent stem cells (iPSC) from patients carrying a heterozygous mutation in the gene encoding STING. The gain-of-function mutation leads to constitutive activation of STING which leads to the development of the disease STING-associated vasculopathy with onset...

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Detalles Bibliográficos
Autores principales: Mehta, Atul, Yu, Quan, Liu, Yangtengyu, Yang, Dan, Zou, Jizhong, Beers, Jeanette, de Jesus Rasheed, Adriana A, Rastegar, Andrew T., Goldbach-Mansky, Raphaela, Boehm, Manfred, Chen, Guibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799028/
https://www.ncbi.nlm.nih.gov/pubmed/36399927
http://dx.doi.org/10.1016/j.scr.2022.102974

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