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Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing

RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) develop more severe coronavirus disease (COVID-19); however, it is unclear whether they are more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and what mechanisms are responsible for severe...

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Detalles Bibliográficos
Autores principales:	Johansen, Matt D., Mahbub, Rashad M., Idrees, Sobia, Nguyen, Duc H., Miemczyk, Stefan, Pathinayake, Prabuddha, Nichol, Kristy, Hansbro, Nicole G., Gearing, Linden J., Hertzog, Paul J., Gallego-Ortega, David, Britton, Warwick J., Saunders, Bernadette M., Wark, Peter A., Faiz, Alen, Hansbro, Philip M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799113/ https://www.ncbi.nlm.nih.gov/pubmed/35549656 http://dx.doi.org/10.1164/rccm.202108-1901OC

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