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Indirect protection of children from SARS-CoV-2 infection through parental vaccination

Children not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may still benefit from vaccines through protection from vaccinated contacts. We estimated the protection provided to children through parental vaccination with the BNT162b2 vaccine. We studied households wit...

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Autores principales: Hayek, Samah, Shaham, Galit, Ben-Shlomo, Yatir, Kepten, Eldad, Dagan, Noa, Nevo, Daniel, Lipsitch, Marc, Reis, Ben Y., Balicer, Ran D., Barda, Noam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799368/
https://www.ncbi.nlm.nih.gov/pubmed/35084938
http://dx.doi.org/10.1126/science.abm3087
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author Hayek, Samah
Shaham, Galit
Ben-Shlomo, Yatir
Kepten, Eldad
Dagan, Noa
Nevo, Daniel
Lipsitch, Marc
Reis, Ben Y.
Balicer, Ran D.
Barda, Noam
author_facet Hayek, Samah
Shaham, Galit
Ben-Shlomo, Yatir
Kepten, Eldad
Dagan, Noa
Nevo, Daniel
Lipsitch, Marc
Reis, Ben Y.
Balicer, Ran D.
Barda, Noam
author_sort Hayek, Samah
collection PubMed
description Children not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may still benefit from vaccines through protection from vaccinated contacts. We estimated the protection provided to children through parental vaccination with the BNT162b2 vaccine. We studied households without prior infection consisting of two parents and unvaccinated children, estimating the effect of parental vaccination on the risk of infection for unvaccinated children. We studied two periods separately—an early period (17 January 2021 to 28 March 2021; Alpha variant, two doses versus no vaccination) and a late period (11 July 2021 to 30 September 2021; Delta variant, booster dose versus two vaccine doses). We found that having a single vaccinated parent was associated with a 26.0 and a 20.8% decreased risk in the early and late periods, respectively, and having two vaccinated parents was associated with a 71.7 and a 58.1% decreased risk, respectively. Thus, parental vaccination confers substantial protection on unvaccinated children in the household.
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spelling pubmed-97993682023-01-06 Indirect protection of children from SARS-CoV-2 infection through parental vaccination Hayek, Samah Shaham, Galit Ben-Shlomo, Yatir Kepten, Eldad Dagan, Noa Nevo, Daniel Lipsitch, Marc Reis, Ben Y. Balicer, Ran D. Barda, Noam Science Reports Children not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may still benefit from vaccines through protection from vaccinated contacts. We estimated the protection provided to children through parental vaccination with the BNT162b2 vaccine. We studied households without prior infection consisting of two parents and unvaccinated children, estimating the effect of parental vaccination on the risk of infection for unvaccinated children. We studied two periods separately—an early period (17 January 2021 to 28 March 2021; Alpha variant, two doses versus no vaccination) and a late period (11 July 2021 to 30 September 2021; Delta variant, booster dose versus two vaccine doses). We found that having a single vaccinated parent was associated with a 26.0 and a 20.8% decreased risk in the early and late periods, respectively, and having two vaccinated parents was associated with a 71.7 and a 58.1% decreased risk, respectively. Thus, parental vaccination confers substantial protection on unvaccinated children in the household. American Association for the Advancement of Science 2022-01-27 2022-03-11 /pmc/articles/PMC9799368/ /pubmed/35084938 http://dx.doi.org/10.1126/science.abm3087 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Hayek, Samah
Shaham, Galit
Ben-Shlomo, Yatir
Kepten, Eldad
Dagan, Noa
Nevo, Daniel
Lipsitch, Marc
Reis, Ben Y.
Balicer, Ran D.
Barda, Noam
Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title_full Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title_fullStr Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title_full_unstemmed Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title_short Indirect protection of children from SARS-CoV-2 infection through parental vaccination
title_sort indirect protection of children from sars-cov-2 infection through parental vaccination
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799368/
https://www.ncbi.nlm.nih.gov/pubmed/35084938
http://dx.doi.org/10.1126/science.abm3087
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