Cargando…
Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making
Memory-guided decision making involves long-range coordination across sensory and cognitive brain networks, with key roles for the hippocampus and prefrontal cortex (PFC). In order to investigate the mechanisms of such coordination, we monitored activity in hippocampus (CA1), PFC, and olfactory bulb...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799972/ https://www.ncbi.nlm.nih.gov/pubmed/36480255 http://dx.doi.org/10.7554/eLife.79545 |
_version_ | 1784861193877323776 |
---|---|
author | Symanski, Claire A Bladon, John H Kullberg, Emi T Miller, Paul Jadhav, Shantanu P |
author_facet | Symanski, Claire A Bladon, John H Kullberg, Emi T Miller, Paul Jadhav, Shantanu P |
author_sort | Symanski, Claire A |
collection | PubMed |
description | Memory-guided decision making involves long-range coordination across sensory and cognitive brain networks, with key roles for the hippocampus and prefrontal cortex (PFC). In order to investigate the mechanisms of such coordination, we monitored activity in hippocampus (CA1), PFC, and olfactory bulb (OB) in rats performing an odor-place associative memory guided decision task on a T-maze. During odor sampling, the beta (20–30 Hz) and respiratory (7–8 Hz) rhythms (RR) were prominent across the three regions, with beta and RR coherence between all pairs of regions enhanced during the odor-cued decision making period. Beta phase modulation of phase-locked CA1 and PFC neurons during this period was linked to accurate decisions, with a key role of CA1 interneurons in temporal coordination. Single neurons and ensembles in both CA1 and PFC encoded and predicted animals’ upcoming choices, with different cell ensembles engaged during decision-making and decision execution on the maze. Our findings indicate that rhythmic coordination within the hippocampal-prefrontal-olfactory bulb network supports utilization of odor cues for memory-guided decision making. |
format | Online Article Text |
id | pubmed-9799972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-97999722022-12-30 Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making Symanski, Claire A Bladon, John H Kullberg, Emi T Miller, Paul Jadhav, Shantanu P eLife Neuroscience Memory-guided decision making involves long-range coordination across sensory and cognitive brain networks, with key roles for the hippocampus and prefrontal cortex (PFC). In order to investigate the mechanisms of such coordination, we monitored activity in hippocampus (CA1), PFC, and olfactory bulb (OB) in rats performing an odor-place associative memory guided decision task on a T-maze. During odor sampling, the beta (20–30 Hz) and respiratory (7–8 Hz) rhythms (RR) were prominent across the three regions, with beta and RR coherence between all pairs of regions enhanced during the odor-cued decision making period. Beta phase modulation of phase-locked CA1 and PFC neurons during this period was linked to accurate decisions, with a key role of CA1 interneurons in temporal coordination. Single neurons and ensembles in both CA1 and PFC encoded and predicted animals’ upcoming choices, with different cell ensembles engaged during decision-making and decision execution on the maze. Our findings indicate that rhythmic coordination within the hippocampal-prefrontal-olfactory bulb network supports utilization of odor cues for memory-guided decision making. eLife Sciences Publications, Ltd 2022-12-08 /pmc/articles/PMC9799972/ /pubmed/36480255 http://dx.doi.org/10.7554/eLife.79545 Text en © 2022, Symanski, Bladon et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Symanski, Claire A Bladon, John H Kullberg, Emi T Miller, Paul Jadhav, Shantanu P Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title | Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title_full | Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title_fullStr | Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title_full_unstemmed | Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title_short | Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
title_sort | rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799972/ https://www.ncbi.nlm.nih.gov/pubmed/36480255 http://dx.doi.org/10.7554/eLife.79545 |
work_keys_str_mv | AT symanskiclairea rhythmiccoordinationandensembledynamicsinthehippocampalprefrontalnetworkduringodorplaceassociativememoryanddecisionmaking AT bladonjohnh rhythmiccoordinationandensembledynamicsinthehippocampalprefrontalnetworkduringodorplaceassociativememoryanddecisionmaking AT kullbergemit rhythmiccoordinationandensembledynamicsinthehippocampalprefrontalnetworkduringodorplaceassociativememoryanddecisionmaking AT millerpaul rhythmiccoordinationandensembledynamicsinthehippocampalprefrontalnetworkduringodorplaceassociativememoryanddecisionmaking AT jadhavshantanup rhythmiccoordinationandensembledynamicsinthehippocampalprefrontalnetworkduringodorplaceassociativememoryanddecisionmaking |