Comparison of different gene addition strategies to modify placental derived-mesenchymal stromal cells to produce FVIII

INTRODUCTION: Placenta-derived mesenchymal cells (PLCs) endogenously produce FVIII, which makes them ideally suited for cell-based fVIII gene delivery. We have previously reported that human PLCs can be efficiently modified with a lentiviral vector encoding a bioengineered, expression/secretion-opti...

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Detalles Bibliográficos
Autores principales: Ramamurthy, Ritu M., Rodriguez, Martin, Ainsworth, Hannah C., Shields, Jordan, Meares, Diane, Bishop, Colin, Farland, Andrew, Langefeld, Carl D., Atala, Anthony, Doering, Christopher B., Spencer, H. Trent, Porada, Christopher D., Almeida-Porada, Graça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800010/
https://www.ncbi.nlm.nih.gov/pubmed/36591257
http://dx.doi.org/10.3389/fimmu.2022.954984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800010/
https://www.ncbi.nlm.nih.gov/pubmed/36591257
http://dx.doi.org/10.3389/fimmu.2022.954984

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