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Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis
Background In recent years, cyclooxygenase-2 (COX-2) has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic significance of COX-2 in glioma patients remains controversial. Objective To evaluate the correlation of COX-2 with the prognosis in gli...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800163/ https://www.ncbi.nlm.nih.gov/pubmed/36580964 http://dx.doi.org/10.1055/s-0042-1758864 |
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author | Wang, Jun Xiang, Chenyan Cai, Yi Mei, Ziyi Lu, Qianqian Liu, Binbin Zou, Lili |
author_facet | Wang, Jun Xiang, Chenyan Cai, Yi Mei, Ziyi Lu, Qianqian Liu, Binbin Zou, Lili |
author_sort | Wang, Jun |
collection | PubMed |
description | Background In recent years, cyclooxygenase-2 (COX-2) has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic significance of COX-2 in glioma patients remains controversial. Objective To evaluate the correlation of COX-2 with the prognosis in glioma patients. Methods Eligible studies on this subject were included, and pooled odd ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Publication bias was assessed through funnel plots, and heterogeneity and sensitivity were analyzed as well. Results In the present study, 11 articles with a total of 641 patients were included. The high expression of COX-2 in glioma patients was negatively associated with overall survival (OS) (n = 11; HR = 2.26; 95%CI = 1.79–2.86), and the subgroup analysis showed no differences in OS between Asian (n = 5; HR = 2.16; 95%CI = 1.57–2.97) and non-Asian (n = 6; HR = 2.39; 95%CI = 1.69–3.38) glioma patients. The Begg funnel plots test indicated that there was no evident risk of publication bias in the meta-analysis. Conclusion The present study suggests that COX-2 could be recommended as a useful pathological and prognostic biomarker in the clinical practice. |
format | Online Article Text |
id | pubmed-9800163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98001632023-01-09 Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis Wang, Jun Xiang, Chenyan Cai, Yi Mei, Ziyi Lu, Qianqian Liu, Binbin Zou, Lili Arq Neuropsiquiatr Background In recent years, cyclooxygenase-2 (COX-2) has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic significance of COX-2 in glioma patients remains controversial. Objective To evaluate the correlation of COX-2 with the prognosis in glioma patients. Methods Eligible studies on this subject were included, and pooled odd ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Publication bias was assessed through funnel plots, and heterogeneity and sensitivity were analyzed as well. Results In the present study, 11 articles with a total of 641 patients were included. The high expression of COX-2 in glioma patients was negatively associated with overall survival (OS) (n = 11; HR = 2.26; 95%CI = 1.79–2.86), and the subgroup analysis showed no differences in OS between Asian (n = 5; HR = 2.16; 95%CI = 1.57–2.97) and non-Asian (n = 6; HR = 2.39; 95%CI = 1.69–3.38) glioma patients. The Begg funnel plots test indicated that there was no evident risk of publication bias in the meta-analysis. Conclusion The present study suggests that COX-2 could be recommended as a useful pathological and prognostic biomarker in the clinical practice. Thieme Revinter Publicações Ltda. 2022-12-29 /pmc/articles/PMC9800163/ /pubmed/36580964 http://dx.doi.org/10.1055/s-0042-1758864 Text en Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Wang, Jun Xiang, Chenyan Cai, Yi Mei, Ziyi Lu, Qianqian Liu, Binbin Zou, Lili Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title | Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title_full | Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title_fullStr | Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title_full_unstemmed | Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title_short | Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis |
title_sort | clinicopathological and prognostic significance of cox-2 in glioma patients: a meta-analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800163/ https://www.ncbi.nlm.nih.gov/pubmed/36580964 http://dx.doi.org/10.1055/s-0042-1758864 |
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