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Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA
The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA sequencing to identify genes that may influence transfect...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800263/ https://www.ncbi.nlm.nih.gov/pubmed/36618265 http://dx.doi.org/10.1016/j.omtn.2022.11.025 |