Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

Huntington disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene that alters cellular homeostasis, particularly in the striatum and cortex. Astrocyte signaling that establishes and maintains neuronal functions are often altered under pathological conditio...

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Detalles Bibliográficos
Autores principales: Reyes-Ortiz, Andrea M., Abud, Edsel M., Burns, Mara S., Wu, Jie, Hernandez, Sarah J., McClure, Nicolette, Wang, Keona Q., Schulz, Corey J., Miramontes, Ricardo, Lau, Alice, Michael, Neethu, Miyoshi, Emily, Van Vactor, David, Reidling, John C., Blurton-Jones, Mathew, Swarup, Vivek, Poon, Wayne W., Lim, Ryan G., Thompson, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800269/
https://www.ncbi.nlm.nih.gov/pubmed/36590162
http://dx.doi.org/10.1016/j.isci.2022.105732

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