Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial

Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 (ANGPTL3)—as a potent chondrogenesis inducer using a phenotypic screen with human mesenchymal stem cells. We show that LNA043 promo...

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Detalles Bibliográficos
Autores principales: Gerwin, Nicole, Scotti, Celeste, Halleux, Christine, Fornaro, Mara, Elliott, Jimmy, Zhang, Yunyu, Johnson, Kristen, Shi, Jian, Walter, Sandra, Li, Yufei, Jacobi, Carsten, Laplanche, Nelly, Belaud, Magali, Paul, Jochen, Glowacki, Gustavo, Peters, Thomas, Wharton, Keith A., Vostiar, Igor, Polus, Florine, Kramer, Ina, Guth, Sabine, Seroutou, Abdelkader, Choudhury, Subhajit, Laurent, Didier, Gimbel, Joseph, Goldhahn, Jörg, Schieker, Matthias, Brachat, Sophie, Roubenoff, Ronenn, Kneissel, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800282/
https://www.ncbi.nlm.nih.gov/pubmed/36456835
http://dx.doi.org/10.1038/s41591-022-02059-9

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