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A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Ca(v)3.2-dependent pain by sequestering exogenous and endogenous sulfide

Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132), an organogermanium, is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGP) in aqueous solutions, and reduces inflammation, pain and cancer, whereas the underlying mechanisms remain unknown. Sulfides including H(2)S, a gasotransmitter, gener...

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Detalles Bibliográficos
Autores principales:	Sekiguchi, Fumiko, Koike, Nene, Shimada, Yasuhiro, Sugimoto, Kaho, Masuda, Hiroshi, Nakamura, Takashi, Yamaguchi, Hiroaki, Tanabe, Genzoh, Marumoto, Shinsuke, Kasanami, Yoshihito, Tsubota, Maho, Ohkubo, Tsuyako, Yoshida, Shigeru, Kawabata, Atsufumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800310/ https://www.ncbi.nlm.nih.gov/pubmed/36563535 http://dx.doi.org/10.1016/j.redox.2022.102579

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