A transcriptome dataset for gonadectomy-induced changes in rat spinal cord

Circulating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits...

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Detalles Bibliográficos
Autores principales: Miller, Shawn, Abrahante, Juan E., Roopra, Avtar, Dougherty, Brendan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800375/
https://www.ncbi.nlm.nih.gov/pubmed/36581616
http://dx.doi.org/10.1038/s41597-022-01917-y
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author Miller, Shawn
Abrahante, Juan E.
Roopra, Avtar
Dougherty, Brendan J.
author_facet Miller, Shawn
Abrahante, Juan E.
Roopra, Avtar
Dougherty, Brendan J.
author_sort Miller, Shawn
collection PubMed
description Circulating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits; less is known regarding hormonal influence of ventral spinal motor function. Gonadectomy (surgical removal of the testes in males and ovaries in females) rapidly and persistently reduces circulating sex steroids in both females and males, providing a means to interrogate the role of hormones on neural function. Here we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the impact of gonadectomy on the transcriptome of ventral spinal cord tissue of adult female and male rats.
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spelling pubmed-98003752022-12-31 A transcriptome dataset for gonadectomy-induced changes in rat spinal cord Miller, Shawn Abrahante, Juan E. Roopra, Avtar Dougherty, Brendan J. Sci Data Data Descriptor Circulating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits; less is known regarding hormonal influence of ventral spinal motor function. Gonadectomy (surgical removal of the testes in males and ovaries in females) rapidly and persistently reduces circulating sex steroids in both females and males, providing a means to interrogate the role of hormones on neural function. Here we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the impact of gonadectomy on the transcriptome of ventral spinal cord tissue of adult female and male rats. Nature Publishing Group UK 2022-12-29 /pmc/articles/PMC9800375/ /pubmed/36581616 http://dx.doi.org/10.1038/s41597-022-01917-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Miller, Shawn
Abrahante, Juan E.
Roopra, Avtar
Dougherty, Brendan J.
A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title_full A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title_fullStr A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title_full_unstemmed A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title_short A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
title_sort transcriptome dataset for gonadectomy-induced changes in rat spinal cord
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800375/
https://www.ncbi.nlm.nih.gov/pubmed/36581616
http://dx.doi.org/10.1038/s41597-022-01917-y
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