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Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports
High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patie...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800515/ https://www.ncbi.nlm.nih.gov/pubmed/36591464 http://dx.doi.org/10.3389/fonc.2022.1073036 |
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author | Solár, Peter Mackerle, Zdenek Hendrych, Michal Pospisil, Petr Lakomy, Radek Valekova, Hana Hermanova, Marketa Jancalek, Radim |
author_facet | Solár, Peter Mackerle, Zdenek Hendrych, Michal Pospisil, Petr Lakomy, Radek Valekova, Hana Hermanova, Marketa Jancalek, Radim |
author_sort | Solár, Peter |
collection | PubMed |
description | High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection. |
format | Online Article Text |
id | pubmed-9800515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98005152022-12-31 Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports Solár, Peter Mackerle, Zdenek Hendrych, Michal Pospisil, Petr Lakomy, Radek Valekova, Hana Hermanova, Marketa Jancalek, Radim Front Oncol Oncology High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection. Frontiers Media S.A. 2022-12-16 /pmc/articles/PMC9800515/ /pubmed/36591464 http://dx.doi.org/10.3389/fonc.2022.1073036 Text en Copyright © 2022 Solár, Mackerle, Hendrych, Pospisil, Lakomy, Valekova, Hermanova and Jancalek https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Solár, Peter Mackerle, Zdenek Hendrych, Michal Pospisil, Petr Lakomy, Radek Valekova, Hana Hermanova, Marketa Jancalek, Radim Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title | Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title_full | Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title_fullStr | Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title_full_unstemmed | Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title_short | Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports |
title_sort | prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800515/ https://www.ncbi.nlm.nih.gov/pubmed/36591464 http://dx.doi.org/10.3389/fonc.2022.1073036 |
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