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Immunomodulatory role of metalloproteases in cancers: Current progress and future trends
Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800621/ https://www.ncbi.nlm.nih.gov/pubmed/36591235 http://dx.doi.org/10.3389/fimmu.2022.1064033 |
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author | Wang, Qi Wang, Kai Tan, Xiaojing Li, Zhenxiang Wang, Haiyong |
author_facet | Wang, Qi Wang, Kai Tan, Xiaojing Li, Zhenxiang Wang, Haiyong |
author_sort | Wang, Qi |
collection | PubMed |
description | Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs with Thrombospondin Motifs (ADAMTS). They have various functions such as protein hydrolysis, cell adhesion and remodeling of extracellular matrix. Metalloproteinases expressed in multiple types of cancers and participate in many pathological processes involving tumor genesis and development, invasion and metastasis by regulating signal transduction and tumor microenvironment. In this review, based on the current research progress, we summarized the structure of MPs, their expression and especially immunomodulatory role and mechanisms in cancers. Additionally, a relevant and timely update of recent advances and future directions were provided for the diagnosis and immunotherapy targeting MPs in cancers. |
format | Online Article Text |
id | pubmed-9800621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98006212022-12-31 Immunomodulatory role of metalloproteases in cancers: Current progress and future trends Wang, Qi Wang, Kai Tan, Xiaojing Li, Zhenxiang Wang, Haiyong Front Immunol Immunology Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteases (ADAMs) and ADAMs with Thrombospondin Motifs (ADAMTS). They have various functions such as protein hydrolysis, cell adhesion and remodeling of extracellular matrix. Metalloproteinases expressed in multiple types of cancers and participate in many pathological processes involving tumor genesis and development, invasion and metastasis by regulating signal transduction and tumor microenvironment. In this review, based on the current research progress, we summarized the structure of MPs, their expression and especially immunomodulatory role and mechanisms in cancers. Additionally, a relevant and timely update of recent advances and future directions were provided for the diagnosis and immunotherapy targeting MPs in cancers. Frontiers Media S.A. 2022-12-16 /pmc/articles/PMC9800621/ /pubmed/36591235 http://dx.doi.org/10.3389/fimmu.2022.1064033 Text en Copyright © 2022 Wang, Wang, Tan, Li and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Qi Wang, Kai Tan, Xiaojing Li, Zhenxiang Wang, Haiyong Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title_full | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title_fullStr | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title_full_unstemmed | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title_short | Immunomodulatory role of metalloproteases in cancers: Current progress and future trends |
title_sort | immunomodulatory role of metalloproteases in cancers: current progress and future trends |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800621/ https://www.ncbi.nlm.nih.gov/pubmed/36591235 http://dx.doi.org/10.3389/fimmu.2022.1064033 |
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