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Rapid excision of oxidized adenine by human thymine DNA glycosylase

Oxidation of DNA bases generates mutagenic and cytotoxic lesions that are implicated in cancer and other diseases. Oxidative base lesions, including 7,8-dihydro-8-oxoguanine, are typically removed through base excision repair. In addition, oxidized deoxynucleotides such as 8-oxo-dGTP are depleted by...

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Detalles Bibliográficos
Autores principales:	Servius, Hardler W., Pidugu, Lakshmi S., Sherman, Matthew E., Drohat, Alexander C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800633/ https://www.ncbi.nlm.nih.gov/pubmed/36460098 http://dx.doi.org/10.1016/j.jbc.2022.102756

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