Mutational signature of mtDNA confers mechanistic insight into oxidative metabolism remodeling in colorectal cancer

Rationale: Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutations and subsequent metabolic defects are closely involved in tumorigenesis and progression in a cancer-type specific manner. To date, the mutational pattern of mtDNA somatic mutations in colorectal cancer (CRC) tissues an...

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Detalles Bibliográficos
Autores principales: Guo, Wenjie, Liu, Yang, Ji, Xiaoying, Guo, Shanshan, Xie, Fanfan, Chen, Yanxing, Zhou, Kaixiang, Zhang, Huanqin, Peng, Fan, Wu, Dan, Wang, Zhenni, Guo, Xu, zhao, Qi, Gu, Xiwen, Xing, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800724/
https://www.ncbi.nlm.nih.gov/pubmed/36593960
http://dx.doi.org/10.7150/thno.78718

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