DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid leukemia progression, and determine the sensitivity of BCL2 inhibitor venetoclax

Rationale: microRNAs (miRNAs) are frequently deregulated and play important roles in the pathogenesis and progression of acute myeloid leukemia (AML). miR-182 functions as an onco-miRNA or tumor suppressor miRNA in the context of different cancers. However, whether miR-182 affects the self-renewal o...

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Detalles Bibliográficos
Autores principales: Ye, Sisi, Xiong, Fang, He, Xiaofei, Yuan, Yigang, Li, Danyang, Ye, Daijiao, Shi, Liuzhi, Lin, Zihan, Zhao, Min, Feng, Shuya, Zhou, Bin, Weng, Huachun, Hong, Lili, Ye, Haige, Gao, Shenmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800726/
https://www.ncbi.nlm.nih.gov/pubmed/36593968
http://dx.doi.org/10.7150/thno.77404

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