Mitochondrial uncoupler DNP induces coexistence of dual-state hyper-energy metabolism leading to tumor growth advantage in human glioma xenografts

INTRODUCTION: Cancer bioenergetics is an essential hallmark of neoplastic transformation. Warburg postulated that mitochondrial OXPHOS is impaired in cancer cells, leading to aerobic glycolysis as the primary metabolic pathway. However, mitochondrial function is altered but not entirely compromised...

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Detalles Bibliográficos
Autores principales: Rai, Yogesh, Singh, Saurabh, Pandey, Sanjay, Sah, Dhananjay, Sah, Raj Kumar, Roy, B. G., Dwarakanath, Bilikere S., Bhatt, Anant Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800826/
https://www.ncbi.nlm.nih.gov/pubmed/36591481
http://dx.doi.org/10.3389/fonc.2022.1063531

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