Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment

The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon. In three comorbid pain and depression animal models (gen...

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Detalles Bibliográficos
Autores principales: Dai, Jiajia, Kim, Hyangin, You, Zerong, McCabe, Michael F., Zhang, Shuzhuo, Wang, Shiyu, Lim, Grewo, Chen, Lucy, Mao, Jianren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800882/
https://www.ncbi.nlm.nih.gov/pubmed/36588734
http://dx.doi.org/10.3389/fphar.2022.1084108

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