Cargando…

A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment

Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuanbiao, Fan, Lei, Jiang, Xinlin, Lu, Yi, Li, Yige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800931/
https://www.ncbi.nlm.nih.gov/pubmed/36590060
http://dx.doi.org/10.3389/fnhum.2022.1061916
_version_ 1784861392612884480
author Liu, Yuanbiao
Fan, Lei
Jiang, Xinlin
Lu, Yi
Li, Yige
author_facet Liu, Yuanbiao
Fan, Lei
Jiang, Xinlin
Lu, Yi
Li, Yige
author_sort Liu, Yuanbiao
collection PubMed
description Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities. The cognitive assessment indicated that, although her cognitive function was impaired, especially executive function, it largely improved after receiving anti-infectious and repetitive transcranial magnetic stimulation, which can alter the membrane potential of the cortical nerve cells by triggering long-term potentiation and depression, modulating and releasing hormones, reducing the level of neuroinflammatory and peripheral blood cytokines, promoting nerve regeneration and synaptic remodeling, and changing the activity of the neural circuitry of the dorsolateral prefrontal cortex. We argue that this case provides a novel method of treatment for patients with CM in conjunction with cognitive impairments.
format Online
Article
Text
id pubmed-9800931
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98009312022-12-31 A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment Liu, Yuanbiao Fan, Lei Jiang, Xinlin Lu, Yi Li, Yige Front Hum Neurosci Human Neuroscience Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities. The cognitive assessment indicated that, although her cognitive function was impaired, especially executive function, it largely improved after receiving anti-infectious and repetitive transcranial magnetic stimulation, which can alter the membrane potential of the cortical nerve cells by triggering long-term potentiation and depression, modulating and releasing hormones, reducing the level of neuroinflammatory and peripheral blood cytokines, promoting nerve regeneration and synaptic remodeling, and changing the activity of the neural circuitry of the dorsolateral prefrontal cortex. We argue that this case provides a novel method of treatment for patients with CM in conjunction with cognitive impairments. Frontiers Media S.A. 2022-12-16 /pmc/articles/PMC9800931/ /pubmed/36590060 http://dx.doi.org/10.3389/fnhum.2022.1061916 Text en Copyright © 2022 Liu, Fan, Jiang, Lu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Liu, Yuanbiao
Fan, Lei
Jiang, Xinlin
Lu, Yi
Li, Yige
A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title_full A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title_fullStr A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title_full_unstemmed A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title_short A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
title_sort case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800931/
https://www.ncbi.nlm.nih.gov/pubmed/36590060
http://dx.doi.org/10.3389/fnhum.2022.1061916
work_keys_str_mv AT liuyuanbiao acasestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT fanlei acasestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT jiangxinlin acasestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT luyi acasestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT liyige acasestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT liuyuanbiao casestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT fanlei casestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT jiangxinlin casestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT luyi casestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment
AT liyige casestudyofrepetitivetranscranialmagneticstimulationforcryptococcalmeningitiscombinedwithcognitiveimpairment