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A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment
Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800931/ https://www.ncbi.nlm.nih.gov/pubmed/36590060 http://dx.doi.org/10.3389/fnhum.2022.1061916 |
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author | Liu, Yuanbiao Fan, Lei Jiang, Xinlin Lu, Yi Li, Yige |
author_facet | Liu, Yuanbiao Fan, Lei Jiang, Xinlin Lu, Yi Li, Yige |
author_sort | Liu, Yuanbiao |
collection | PubMed |
description | Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities. The cognitive assessment indicated that, although her cognitive function was impaired, especially executive function, it largely improved after receiving anti-infectious and repetitive transcranial magnetic stimulation, which can alter the membrane potential of the cortical nerve cells by triggering long-term potentiation and depression, modulating and releasing hormones, reducing the level of neuroinflammatory and peripheral blood cytokines, promoting nerve regeneration and synaptic remodeling, and changing the activity of the neural circuitry of the dorsolateral prefrontal cortex. We argue that this case provides a novel method of treatment for patients with CM in conjunction with cognitive impairments. |
format | Online Article Text |
id | pubmed-9800931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98009312022-12-31 A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment Liu, Yuanbiao Fan, Lei Jiang, Xinlin Lu, Yi Li, Yige Front Hum Neurosci Human Neuroscience Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities. The cognitive assessment indicated that, although her cognitive function was impaired, especially executive function, it largely improved after receiving anti-infectious and repetitive transcranial magnetic stimulation, which can alter the membrane potential of the cortical nerve cells by triggering long-term potentiation and depression, modulating and releasing hormones, reducing the level of neuroinflammatory and peripheral blood cytokines, promoting nerve regeneration and synaptic remodeling, and changing the activity of the neural circuitry of the dorsolateral prefrontal cortex. We argue that this case provides a novel method of treatment for patients with CM in conjunction with cognitive impairments. Frontiers Media S.A. 2022-12-16 /pmc/articles/PMC9800931/ /pubmed/36590060 http://dx.doi.org/10.3389/fnhum.2022.1061916 Text en Copyright © 2022 Liu, Fan, Jiang, Lu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Liu, Yuanbiao Fan, Lei Jiang, Xinlin Lu, Yi Li, Yige A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title | A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title_full | A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title_fullStr | A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title_full_unstemmed | A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title_short | A case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
title_sort | case study of repetitive transcranial magnetic stimulation for cryptococcal meningitis combined with cognitive impairment |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800931/ https://www.ncbi.nlm.nih.gov/pubmed/36590060 http://dx.doi.org/10.3389/fnhum.2022.1061916 |
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