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Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives

BACKGROUND: Epilepsy is one of the most common neurological disorders. Approximately, one-third of patients with epilepsy have seizures refractory to antiepileptic drugs and further require surgical removal of the epileptogenic region. In the last decade, there have been many recent developments in...

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Autores principales: Sukprakun, Chanan, Tepmongkol, Supatporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800996/
https://www.ncbi.nlm.nih.gov/pubmed/36588897
http://dx.doi.org/10.3389/fneur.2022.1083775
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author Sukprakun, Chanan
Tepmongkol, Supatporn
author_facet Sukprakun, Chanan
Tepmongkol, Supatporn
author_sort Sukprakun, Chanan
collection PubMed
description BACKGROUND: Epilepsy is one of the most common neurological disorders. Approximately, one-third of patients with epilepsy have seizures refractory to antiepileptic drugs and further require surgical removal of the epileptogenic region. In the last decade, there have been many recent developments in radiopharmaceuticals, novel image analysis techniques, and new software for an epileptogenic zone (EZ) localization. OBJECTIVES: Recently, we provided the latest discoveries, current challenges, and future perspectives in the field of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in epilepsy. METHODS: We searched for relevant articles published in MEDLINE and CENTRAL from July 2012 to July 2022. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis was conducted using the keywords “Epilepsy” and “PET or SPECT.” We included both prospective and retrospective studies. Studies with preclinical subjects or not focusing on EZ localization or surgical outcome prediction using recently developed PET radiopharmaceuticals, novel image analysis techniques, and new software were excluded from the review. The remaining 162 articles were reviewed. RESULTS: We first present recent findings and developments in PET radiopharmaceuticals. Second, we present novel image analysis techniques and new software in the last decade for EZ localization. Finally, we summarize the overall findings and discuss future perspectives in the field of PET and SPECT in epilepsy. CONCLUSION: Combining new radiopharmaceutical development, new indications, new techniques, and software improves EZ localization and provides a better understanding of epilepsy. These have proven not to only predict prognosis but also to improve the outcome of epilepsy surgery.
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spelling pubmed-98009962022-12-31 Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives Sukprakun, Chanan Tepmongkol, Supatporn Front Neurol Neurology BACKGROUND: Epilepsy is one of the most common neurological disorders. Approximately, one-third of patients with epilepsy have seizures refractory to antiepileptic drugs and further require surgical removal of the epileptogenic region. In the last decade, there have been many recent developments in radiopharmaceuticals, novel image analysis techniques, and new software for an epileptogenic zone (EZ) localization. OBJECTIVES: Recently, we provided the latest discoveries, current challenges, and future perspectives in the field of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in epilepsy. METHODS: We searched for relevant articles published in MEDLINE and CENTRAL from July 2012 to July 2022. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis was conducted using the keywords “Epilepsy” and “PET or SPECT.” We included both prospective and retrospective studies. Studies with preclinical subjects or not focusing on EZ localization or surgical outcome prediction using recently developed PET radiopharmaceuticals, novel image analysis techniques, and new software were excluded from the review. The remaining 162 articles were reviewed. RESULTS: We first present recent findings and developments in PET radiopharmaceuticals. Second, we present novel image analysis techniques and new software in the last decade for EZ localization. Finally, we summarize the overall findings and discuss future perspectives in the field of PET and SPECT in epilepsy. CONCLUSION: Combining new radiopharmaceutical development, new indications, new techniques, and software improves EZ localization and provides a better understanding of epilepsy. These have proven not to only predict prognosis but also to improve the outcome of epilepsy surgery. Frontiers Media S.A. 2022-12-16 /pmc/articles/PMC9800996/ /pubmed/36588897 http://dx.doi.org/10.3389/fneur.2022.1083775 Text en Copyright © 2022 Sukprakun and Tepmongkol. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sukprakun, Chanan
Tepmongkol, Supatporn
Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title_full Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title_fullStr Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title_full_unstemmed Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title_short Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives
title_sort nuclear imaging for localization and surgical outcome prediction in epilepsy: a review of latest discoveries and future perspectives
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800996/
https://www.ncbi.nlm.nih.gov/pubmed/36588897
http://dx.doi.org/10.3389/fneur.2022.1083775
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