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Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review

OBJECTIVE: The aim of this study was to report 6 cases of sinonasal/basicranial myxofibrosarcoma and review demographic data, clinical symptoms, diagnostic methods, therapeutic methods, and prognosis on this subject in the literature. METHODS: We conducted a retrospective analysis of six patients re...

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Autores principales: Li, Hongbing, Wang, Huan, Wang, Dehui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801034/
https://www.ncbi.nlm.nih.gov/pubmed/35256287
http://dx.doi.org/10.1016/j.bjorl.2022.02.001
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author Li, Hongbing
Wang, Huan
Wang, Dehui
author_facet Li, Hongbing
Wang, Huan
Wang, Dehui
author_sort Li, Hongbing
collection PubMed
description OBJECTIVE: The aim of this study was to report 6 cases of sinonasal/basicranial myxofibrosarcoma and review demographic data, clinical symptoms, diagnostic methods, therapeutic methods, and prognosis on this subject in the literature. METHODS: We conducted a retrospective analysis of six patients referred to our hospital during a 10-year period from 2010 to 2020. RESULTS: In this series, there were four males and two females. The tumours originated from the maxillary sinus in all six cases. The symptoms were nonspecific, and all patients underwent endoscopic resection alone or combined with open resection. The postoperative period was uneventful. All patients were diagnosed with myxofibrosarcoma. After a median follow-up period of 36 (6–52) months, the recurrence rate of MFS was 66.7% (4/6), and the mortality rate was 50% (3/6). CONCLUSION: Sinonasal/basicranial MFS is a rare neoplasm, and the most common primary site is the maxillary sinus. When diagnosing MFS, osteolysis may help rule out benign lesions. So far surgery is the mainstay of treatment for sinonasal/basicranial MFS. Our surgical strategy using endoscopic resection or endoscopic resection combined with open resection to achieve a negative surgical margin and using re-excision operations to treat relapsed cases may be recommended to rhinologists who treat MFS. Prospective randomised trials are needed to study the role of chemotherapy, radiotherapy, and our surgical strategy for sinonasal/basicranial MFS. Diagnosing patients at an earlier stage and better patient compliance with follow-up plans may improve the prognosis of patients.
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spelling pubmed-98010342022-12-31 Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review Li, Hongbing Wang, Huan Wang, Dehui Braz J Otorhinolaryngol Review Article OBJECTIVE: The aim of this study was to report 6 cases of sinonasal/basicranial myxofibrosarcoma and review demographic data, clinical symptoms, diagnostic methods, therapeutic methods, and prognosis on this subject in the literature. METHODS: We conducted a retrospective analysis of six patients referred to our hospital during a 10-year period from 2010 to 2020. RESULTS: In this series, there were four males and two females. The tumours originated from the maxillary sinus in all six cases. The symptoms were nonspecific, and all patients underwent endoscopic resection alone or combined with open resection. The postoperative period was uneventful. All patients were diagnosed with myxofibrosarcoma. After a median follow-up period of 36 (6–52) months, the recurrence rate of MFS was 66.7% (4/6), and the mortality rate was 50% (3/6). CONCLUSION: Sinonasal/basicranial MFS is a rare neoplasm, and the most common primary site is the maxillary sinus. When diagnosing MFS, osteolysis may help rule out benign lesions. So far surgery is the mainstay of treatment for sinonasal/basicranial MFS. Our surgical strategy using endoscopic resection or endoscopic resection combined with open resection to achieve a negative surgical margin and using re-excision operations to treat relapsed cases may be recommended to rhinologists who treat MFS. Prospective randomised trials are needed to study the role of chemotherapy, radiotherapy, and our surgical strategy for sinonasal/basicranial MFS. Diagnosing patients at an earlier stage and better patient compliance with follow-up plans may improve the prognosis of patients. Elsevier 2022-02-15 /pmc/articles/PMC9801034/ /pubmed/35256287 http://dx.doi.org/10.1016/j.bjorl.2022.02.001 Text en © 2022 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Li, Hongbing
Wang, Huan
Wang, Dehui
Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title_full Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title_fullStr Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title_full_unstemmed Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title_short Sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
title_sort sinonasal/basicranial myxofibrosarcoma: a report of 6 surgical cases combined with a literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801034/
https://www.ncbi.nlm.nih.gov/pubmed/35256287
http://dx.doi.org/10.1016/j.bjorl.2022.02.001
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