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Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease known for its dense tumor stroma. Focal adhesion kinase inhibitor (FAKi), a non-receptor type tyrosine kinase inhibitor, reduces the tumor stroma. G47Δ, a third-generation oncolytic herpes simplex virus type 1, destroys tumor cells selectiv...

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Detalles Bibliográficos
Autores principales:	Yamada, Tomoharu, Tateishi, Ryosuke, Iwai, Miwako, Tanaka, Minoru, Ijichi, Hideaki, Sano, Makoto, Koike, Kazuhiko, Todo, Tomoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801088/ https://www.ncbi.nlm.nih.gov/pubmed/36619294 http://dx.doi.org/10.1016/j.omto.2022.12.001

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