Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Abnormalities that characterize the pathophysiology of type 2 diabetes (T2D) include deficiencies of β-cells and the expansion of α-cells in pancreatic islets, manifested by lower insulin release and glucagon oversecretion. The molecular mechanisms that determine intra-islet interactions between pan...

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Detalles Bibliográficos
Autores principales: Dobosz, Aneta M., Janikiewicz, Justyna, Krogulec, Ewelina, Dziewulska, Anna, Ajduk, Anna, Szpila, Marcin, Nieznańska, Hanna, Szczepankiewicz, Andrzej A., Wypych, Dorota, Dobrzyn, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801219/
https://www.ncbi.nlm.nih.gov/pubmed/36529318
http://dx.doi.org/10.1016/j.molmet.2022.101659

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