Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract

Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells...

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Autores principales: Kingery, Justin R, Chalem, Andrea, Mukerebe, Crispin, Shigella, Peter S, Miyaye, Donald, Magawa, Ruth G, Ward, Maureen, Kalluvya, Samuel E, McCormick, Jason, Maganga, Jane K, Colombe, Soledad, Aristide, Christine, Corstjens, Paul L A M, Lee, Myung Hee, Changalucha, John M, Downs, Jennifer A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801228/
https://www.ncbi.nlm.nih.gov/pubmed/36601557
http://dx.doi.org/10.1093/ofid/ofac657
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author Kingery, Justin R
Chalem, Andrea
Mukerebe, Crispin
Shigella, Peter S
Miyaye, Donald
Magawa, Ruth G
Ward, Maureen
Kalluvya, Samuel E
McCormick, Jason
Maganga, Jane K
Colombe, Soledad
Aristide, Christine
Corstjens, Paul L A M
Lee, Myung Hee
Changalucha, John M
Downs, Jennifer A
author_facet Kingery, Justin R
Chalem, Andrea
Mukerebe, Crispin
Shigella, Peter S
Miyaye, Donald
Magawa, Ruth G
Ward, Maureen
Kalluvya, Samuel E
McCormick, Jason
Maganga, Jane K
Colombe, Soledad
Aristide, Christine
Corstjens, Paul L A M
Lee, Myung Hee
Changalucha, John M
Downs, Jennifer A
author_sort Kingery, Justin R
collection PubMed
description Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.
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spelling pubmed-98012282023-01-03 Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract Kingery, Justin R Chalem, Andrea Mukerebe, Crispin Shigella, Peter S Miyaye, Donald Magawa, Ruth G Ward, Maureen Kalluvya, Samuel E McCormick, Jason Maganga, Jane K Colombe, Soledad Aristide, Christine Corstjens, Paul L A M Lee, Myung Hee Changalucha, John M Downs, Jennifer A Open Forum Infect Dis Brief Report Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women. Oxford University Press 2022-12-07 /pmc/articles/PMC9801228/ /pubmed/36601557 http://dx.doi.org/10.1093/ofid/ofac657 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Kingery, Justin R
Chalem, Andrea
Mukerebe, Crispin
Shigella, Peter S
Miyaye, Donald
Magawa, Ruth G
Ward, Maureen
Kalluvya, Samuel E
McCormick, Jason
Maganga, Jane K
Colombe, Soledad
Aristide, Christine
Corstjens, Paul L A M
Lee, Myung Hee
Changalucha, John M
Downs, Jennifer A
Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title_full Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title_fullStr Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title_full_unstemmed Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title_short Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
title_sort schistosoma mansoni infection is associated with increased monocytes and fewer natural killer t cells in the female genital tract
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801228/
https://www.ncbi.nlm.nih.gov/pubmed/36601557
http://dx.doi.org/10.1093/ofid/ofac657
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