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Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase

BACKGROUND: Alternative (M2)-activated macrophages drive the anti-inflammatory response against sepsis, a leading cause of death in patients suffering from burn injury. Macrophage M2 polarization is intrinsically linked with dominant oxidative phosphorylation (OXPHOS). Glutamine serves as a major an...

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Detalles Bibliográficos
Autores principales:	Zhu, Yuanfeng, Chen, Xiaoli, Lu, Yongling, Xia, Lin, Fan, Shijun, Huang, Qianying, Liu, Xin, Peng, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801296/ https://www.ncbi.nlm.nih.gov/pubmed/36601059 http://dx.doi.org/10.1093/burnst/tkac041

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