A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin

[Image: see text] Proximity-based strategies to degrade proteins have enormous therapeutic potential in medicine, but the technologies are limited to proteins for which small molecule ligands exist. The identification of such ligands for therapeutically relevant but “undruggable” proteins remains ch...

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Detalles Bibliográficos
Autores principales: Shen, Fangfang, Zheng, Ge, Setegne, Mekedlawit, Tenglin, Karin, Izadi, Manizheh, Xie, Henry, Zhai, Liting, Orkin, Stuart H., Dassama, Laura M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801508/
https://www.ncbi.nlm.nih.gov/pubmed/36589886
http://dx.doi.org/10.1021/acscentsci.2c00998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801508/
https://www.ncbi.nlm.nih.gov/pubmed/36589886
http://dx.doi.org/10.1021/acscentsci.2c00998

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